Citrus Flavanone Narirutin, In Vitro and In Silico Mechanistic Antidiabetic Potential

Citrus fruits and juices have been studied extensively for their potential involvement in the prevention of various diseases. Flavanones, the characteristic polyphenols of citrus species, are the primarily compounds responsible for these studied health benefits. Using in silico and in vitro methods,...

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Autores principales:	Ashraf Ahmed Qurtam, Hamza Mechchate, Imane Es-safi, Mohammed Al-zharani, Fahd A. Nasr, Omar M. Noman, Mohammed Aleissa, Hamada Imtara, Abdulmalik M. Aleissa, Mohamed Bouhrim, Ali S. Alqahtani
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	narirutin naringenin rutinoside isonaringin molecular docking mechanism of action enzyme Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/b507aa5416894a1588be2d3560d8365a
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spelling	oai:doaj.org-article:b507aa5416894a1588be2d3560d8365a2021-11-25T18:40:54ZCitrus Flavanone Narirutin, In Vitro and In Silico Mechanistic Antidiabetic Potential10.3390/pharmaceutics131118181999-4923https://doaj.org/article/b507aa5416894a1588be2d3560d8365a2021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1818https://doaj.org/toc/1999-4923Citrus fruits and juices have been studied extensively for their potential involvement in the prevention of various diseases. Flavanones, the characteristic polyphenols of citrus species, are the primarily compounds responsible for these studied health benefits. Using in silico and in vitro methods, we are exploring the possible antidiabetic action of narirutin, a flavanone family member. The goal of the in silico research was to anticipate how narirutin would interact with eight distinct receptors implicated in diabetes control and complications, namely, dipeptidyl-peptidase 4 (DPP4), protein tyrosine phosphatase 1B (PTP1B), free fatty acid receptor 1 (FFAR1), aldose reductase (AldR), glycogen phosphorylase (GP), alpha-amylase (AAM), peroxisome proliferator-activated receptor gamma (PPAR-γ), alpha-glucosidase (AGL), while the in vitro study looked into narirutin’s possible inhibitory impact on alpha-amylase and alpha-glucosidase. The results indicate that the studied citrus flavanone interacted remarkably with most of the receptors and had an excellent inhibitory activity during the in vitro tests suggesting its potent role among the different constituent of the citrus compounds in the management of diabetes and also its complications.Ashraf Ahmed QurtamHamza MechchateImane Es-safiMohammed Al-zharaniFahd A. NasrOmar M. NomanMohammed AleissaHamada ImtaraAbdulmalik M. AleissaMohamed BouhrimAli S. AlqahtaniMDPI AGarticlenarirutinnaringenin rutinosideisonaringinmolecular dockingmechanism of actionenzymePharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1818, p 1818 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	narirutin naringenin rutinoside isonaringin molecular docking mechanism of action enzyme Pharmacy and materia medica RS1-441
spellingShingle	narirutin naringenin rutinoside isonaringin molecular docking mechanism of action enzyme Pharmacy and materia medica RS1-441 Ashraf Ahmed Qurtam Hamza Mechchate Imane Es-safi Mohammed Al-zharani Fahd A. Nasr Omar M. Noman Mohammed Aleissa Hamada Imtara Abdulmalik M. Aleissa Mohamed Bouhrim Ali S. Alqahtani Citrus Flavanone Narirutin, In Vitro and In Silico Mechanistic Antidiabetic Potential
description	Citrus fruits and juices have been studied extensively for their potential involvement in the prevention of various diseases. Flavanones, the characteristic polyphenols of citrus species, are the primarily compounds responsible for these studied health benefits. Using in silico and in vitro methods, we are exploring the possible antidiabetic action of narirutin, a flavanone family member. The goal of the in silico research was to anticipate how narirutin would interact with eight distinct receptors implicated in diabetes control and complications, namely, dipeptidyl-peptidase 4 (DPP4), protein tyrosine phosphatase 1B (PTP1B), free fatty acid receptor 1 (FFAR1), aldose reductase (AldR), glycogen phosphorylase (GP), alpha-amylase (AAM), peroxisome proliferator-activated receptor gamma (PPAR-γ), alpha-glucosidase (AGL), while the in vitro study looked into narirutin’s possible inhibitory impact on alpha-amylase and alpha-glucosidase. The results indicate that the studied citrus flavanone interacted remarkably with most of the receptors and had an excellent inhibitory activity during the in vitro tests suggesting its potent role among the different constituent of the citrus compounds in the management of diabetes and also its complications.
format	article
author	Ashraf Ahmed Qurtam Hamza Mechchate Imane Es-safi Mohammed Al-zharani Fahd A. Nasr Omar M. Noman Mohammed Aleissa Hamada Imtara Abdulmalik M. Aleissa Mohamed Bouhrim Ali S. Alqahtani
author_facet	Ashraf Ahmed Qurtam Hamza Mechchate Imane Es-safi Mohammed Al-zharani Fahd A. Nasr Omar M. Noman Mohammed Aleissa Hamada Imtara Abdulmalik M. Aleissa Mohamed Bouhrim Ali S. Alqahtani
author_sort	Ashraf Ahmed Qurtam
title	Citrus Flavanone Narirutin, In Vitro and In Silico Mechanistic Antidiabetic Potential
title_short	Citrus Flavanone Narirutin, In Vitro and In Silico Mechanistic Antidiabetic Potential
title_full	Citrus Flavanone Narirutin, In Vitro and In Silico Mechanistic Antidiabetic Potential
title_fullStr	Citrus Flavanone Narirutin, In Vitro and In Silico Mechanistic Antidiabetic Potential
title_full_unstemmed	Citrus Flavanone Narirutin, In Vitro and In Silico Mechanistic Antidiabetic Potential
title_sort	citrus flavanone narirutin, in vitro and in silico mechanistic antidiabetic potential
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b507aa5416894a1588be2d3560d8365a
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Citrus Flavanone Narirutin, In Vitro and In Silico Mechanistic Antidiabetic Potential

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