VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread
Signals through VEGF receptor 2 (VEGFR2) increase vascular permeability, promoting cancer progression. Here the authors show that a point mutation in VEGFR2 preventing its auto-phosphorylation leads to reduced metastatic spread and improved response to chemotherapy in tumor-bearing mice, without aff...
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Nature Portfolio
2016
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oai:doaj.org-article:b507e4a16cf547ee96f8120a0c5f03302021-12-02T16:49:27ZVEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread10.1038/ncomms110172041-1723https://doaj.org/article/b507e4a16cf547ee96f8120a0c5f03302016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11017https://doaj.org/toc/2041-1723Signals through VEGF receptor 2 (VEGFR2) increase vascular permeability, promoting cancer progression. Here the authors show that a point mutation in VEGFR2 preventing its auto-phosphorylation leads to reduced metastatic spread and improved response to chemotherapy in tumor-bearing mice, without affecting tumor inflammation.Xiujuan LiNarendra PadhanElisabet O. SjöströmFrancis P. RocheChiara TestiniNaoki HonkuraMiguel Sáinz-JaspeadoEmma GordonKatie BentleyAndrew PhilippidesVladimir TolmachevElisabetta DejanaRadu V. StanDietmar VestweberKurt Ballmer-HoferChrister BetsholtzKristian PietrasLeif JanssonLena Claesson-WelshNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Xiujuan Li Narendra Padhan Elisabet O. Sjöström Francis P. Roche Chiara Testini Naoki Honkura Miguel Sáinz-Jaspeado Emma Gordon Katie Bentley Andrew Philippides Vladimir Tolmachev Elisabetta Dejana Radu V. Stan Dietmar Vestweber Kurt Ballmer-Hofer Christer Betsholtz Kristian Pietras Leif Jansson Lena Claesson-Welsh VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread |
| description |
Signals through VEGF receptor 2 (VEGFR2) increase vascular permeability, promoting cancer progression. Here the authors show that a point mutation in VEGFR2 preventing its auto-phosphorylation leads to reduced metastatic spread and improved response to chemotherapy in tumor-bearing mice, without affecting tumor inflammation. |
| format |
article |
| author |
Xiujuan Li Narendra Padhan Elisabet O. Sjöström Francis P. Roche Chiara Testini Naoki Honkura Miguel Sáinz-Jaspeado Emma Gordon Katie Bentley Andrew Philippides Vladimir Tolmachev Elisabetta Dejana Radu V. Stan Dietmar Vestweber Kurt Ballmer-Hofer Christer Betsholtz Kristian Pietras Leif Jansson Lena Claesson-Welsh |
| author_facet |
Xiujuan Li Narendra Padhan Elisabet O. Sjöström Francis P. Roche Chiara Testini Naoki Honkura Miguel Sáinz-Jaspeado Emma Gordon Katie Bentley Andrew Philippides Vladimir Tolmachev Elisabetta Dejana Radu V. Stan Dietmar Vestweber Kurt Ballmer-Hofer Christer Betsholtz Kristian Pietras Leif Jansson Lena Claesson-Welsh |
| author_sort |
Xiujuan Li |
| title |
VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread |
| title_short |
VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread |
| title_full |
VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread |
| title_fullStr |
VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread |
| title_full_unstemmed |
VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread |
| title_sort |
vegfr2 py949 signalling regulates adherens junction integrity and metastatic spread |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/b507e4a16cf547ee96f8120a0c5f0330 |
| work_keys_str_mv |
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