VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread

Signals through VEGF receptor 2 (VEGFR2) increase vascular permeability, promoting cancer progression. Here the authors show that a point mutation in VEGFR2 preventing its auto-phosphorylation leads to reduced metastatic spread and improved response to chemotherapy in tumor-bearing mice, without aff...

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Auteurs principaux:	Xiujuan Li, Narendra Padhan, Elisabet O. Sjöström, Francis P. Roche, Chiara Testini, Naoki Honkura, Miguel Sáinz-Jaspeado, Emma Gordon, Katie Bentley, Andrew Philippides, Vladimir Tolmachev, Elisabetta Dejana, Radu V. Stan, Dietmar Vestweber, Kurt Ballmer-Hofer, Christer Betsholtz, Kristian Pietras, Leif Jansson, Lena Claesson-Welsh
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/b507e4a16cf547ee96f8120a0c5f0330
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spelling	oai:doaj.org-article:b507e4a16cf547ee96f8120a0c5f03302021-12-02T16:49:27ZVEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread10.1038/ncomms110172041-1723https://doaj.org/article/b507e4a16cf547ee96f8120a0c5f03302016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11017https://doaj.org/toc/2041-1723Signals through VEGF receptor 2 (VEGFR2) increase vascular permeability, promoting cancer progression. Here the authors show that a point mutation in VEGFR2 preventing its auto-phosphorylation leads to reduced metastatic spread and improved response to chemotherapy in tumor-bearing mice, without affecting tumor inflammation.Xiujuan LiNarendra PadhanElisabet O. SjöströmFrancis P. RocheChiara TestiniNaoki HonkuraMiguel Sáinz-JaspeadoEmma GordonKatie BentleyAndrew PhilippidesVladimir TolmachevElisabetta DejanaRadu V. StanDietmar VestweberKurt Ballmer-HoferChrister BetsholtzKristian PietrasLeif JanssonLena Claesson-WelshNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiujuan Li Narendra Padhan Elisabet O. Sjöström Francis P. Roche Chiara Testini Naoki Honkura Miguel Sáinz-Jaspeado Emma Gordon Katie Bentley Andrew Philippides Vladimir Tolmachev Elisabetta Dejana Radu V. Stan Dietmar Vestweber Kurt Ballmer-Hofer Christer Betsholtz Kristian Pietras Leif Jansson Lena Claesson-Welsh VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread
description	Signals through VEGF receptor 2 (VEGFR2) increase vascular permeability, promoting cancer progression. Here the authors show that a point mutation in VEGFR2 preventing its auto-phosphorylation leads to reduced metastatic spread and improved response to chemotherapy in tumor-bearing mice, without affecting tumor inflammation.
format	article
author	Xiujuan Li Narendra Padhan Elisabet O. Sjöström Francis P. Roche Chiara Testini Naoki Honkura Miguel Sáinz-Jaspeado Emma Gordon Katie Bentley Andrew Philippides Vladimir Tolmachev Elisabetta Dejana Radu V. Stan Dietmar Vestweber Kurt Ballmer-Hofer Christer Betsholtz Kristian Pietras Leif Jansson Lena Claesson-Welsh
author_facet	Xiujuan Li Narendra Padhan Elisabet O. Sjöström Francis P. Roche Chiara Testini Naoki Honkura Miguel Sáinz-Jaspeado Emma Gordon Katie Bentley Andrew Philippides Vladimir Tolmachev Elisabetta Dejana Radu V. Stan Dietmar Vestweber Kurt Ballmer-Hofer Christer Betsholtz Kristian Pietras Leif Jansson Lena Claesson-Welsh
author_sort	Xiujuan Li
title	VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread
title_short	VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread
title_full	VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread
title_fullStr	VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread
title_full_unstemmed	VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread
title_sort	vegfr2 py949 signalling regulates adherens junction integrity and metastatic spread
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b507e4a16cf547ee96f8120a0c5f0330
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VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread

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