VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread

VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread

Signals through VEGF receptor 2 (VEGFR2) increase vascular permeability, promoting cancer progression. Here the authors show that a point mutation in VEGFR2 preventing its auto-phosphorylation leads to reduced metastatic spread and improved response to chemotherapy in tumor-bearing mice, without aff...

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Bibliographic Details
Main Authors: Xiujuan Li, Narendra Padhan, Elisabet O. Sjöström, Francis P. Roche, Chiara Testini, Naoki Honkura, Miguel Sáinz-Jaspeado, Emma Gordon, Katie Bentley, Andrew Philippides, Vladimir Tolmachev, Elisabetta Dejana, Radu V. Stan, Dietmar Vestweber, Kurt Ballmer-Hofer, Christer Betsholtz, Kristian Pietras, Leif Jansson, Lena Claesson-Welsh
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
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Online Access:https://doaj.org/article/b507e4a16cf547ee96f8120a0c5f0330
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