Differences between germline and somatic mutation rates in humans and mice

Germline mutation rates are known to vary between species but somatic mutation rates are less well understood. Here the authors compare mice and humans, observing that somatic mutation rates were nearly two orders of magnitude higher in both species, with both mutation rates significantly higher in...

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Autores principales:	Brandon Milholland, Xiao Dong, Lei Zhang, Xiaoxiao Hao, Yousin Suh, Jan Vijg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b50c6055bb5443b5b82b34bb85df6d8b
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id	oai:doaj.org-article:b50c6055bb5443b5b82b34bb85df6d8b
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spelling	oai:doaj.org-article:b50c6055bb5443b5b82b34bb85df6d8b2021-12-02T14:41:10ZDifferences between germline and somatic mutation rates in humans and mice10.1038/ncomms151832041-1723https://doaj.org/article/b50c6055bb5443b5b82b34bb85df6d8b2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15183https://doaj.org/toc/2041-1723Germline mutation rates are known to vary between species but somatic mutation rates are less well understood. Here the authors compare mice and humans, observing that somatic mutation rates were nearly two orders of magnitude higher in both species, with both mutation rates significantly higher in mice.Brandon MilhollandXiao DongLei ZhangXiaoxiao HaoYousin SuhJan VijgNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brandon Milholland Xiao Dong Lei Zhang Xiaoxiao Hao Yousin Suh Jan Vijg Differences between germline and somatic mutation rates in humans and mice
description	Germline mutation rates are known to vary between species but somatic mutation rates are less well understood. Here the authors compare mice and humans, observing that somatic mutation rates were nearly two orders of magnitude higher in both species, with both mutation rates significantly higher in mice.
format	article
author	Brandon Milholland Xiao Dong Lei Zhang Xiaoxiao Hao Yousin Suh Jan Vijg
author_facet	Brandon Milholland Xiao Dong Lei Zhang Xiaoxiao Hao Yousin Suh Jan Vijg
author_sort	Brandon Milholland
title	Differences between germline and somatic mutation rates in humans and mice
title_short	Differences between germline and somatic mutation rates in humans and mice
title_full	Differences between germline and somatic mutation rates in humans and mice
title_fullStr	Differences between germline and somatic mutation rates in humans and mice
title_full_unstemmed	Differences between germline and somatic mutation rates in humans and mice
title_sort	differences between germline and somatic mutation rates in humans and mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b50c6055bb5443b5b82b34bb85df6d8b
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Differences between germline and somatic mutation rates in humans and mice

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