Sphingosine Kinase 1 Signaling in Breast Cancer: A Potential Target to Tackle Breast Cancer Stem Cells

Sphingosine kinases (SPHKs) are conserved lipid enzymes that catalyze the formation of sphingosine-1-phosphate (S1P) through ATP-dependent phosphorylation of sphingosine. Two distinct SPHK isoforms, namely SPHK1 and SPHK2, have been identified to date, and the former has been implicated for its onco...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ling-Wei Hii, Felicia Fei-Lei Chung, Chun-Wai Mai, Pei Yuen Ng, Chee-Onn Leong
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	sphingosine kinase sphingosine-1-phosphate sphingosine-1-phosphate receptor breast cancer cancer stem cells sphingosine kinase inhibitor Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b512e9fc0b7346868f266b6c6bee4419
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b512e9fc0b7346868f266b6c6bee4419
record_format	dspace
spelling	oai:doaj.org-article:b512e9fc0b7346868f266b6c6bee44192021-11-08T05:03:21ZSphingosine Kinase 1 Signaling in Breast Cancer: A Potential Target to Tackle Breast Cancer Stem Cells2296-889X10.3389/fmolb.2021.748470https://doaj.org/article/b512e9fc0b7346868f266b6c6bee44192021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.748470/fullhttps://doaj.org/toc/2296-889XSphingosine kinases (SPHKs) are conserved lipid enzymes that catalyze the formation of sphingosine-1-phosphate (S1P) through ATP-dependent phosphorylation of sphingosine. Two distinct SPHK isoforms, namely SPHK1 and SPHK2, have been identified to date, and the former has been implicated for its oncogenic roles in cancer development and progression. While SPHK1 signaling axis has been extensively studied in non-stem breast cancer cells, recent evidence has emerged to suggest a role of SPHK1 in regulating cancer stem cells (CSCs). With the clinical implications of CSCs in disease relapse and metastasis, it is believed that therapeutic approaches that can eradicate both non-stem cancer cells and CSCs could be a key to cancer cure. In this review, we first explore the oncogenic functions of sphingosine kinase 1 in human cancers and summarize current research findings of SPHK1 signaling with a focus on breast cancer. We also discuss the therapeutic potentials and perspectives of targeting SPHK1 signaling in breast cancer and cancer stem cells. We aim to offer new insights and inspire future studies looking further into the regulatory functions of SPHK1 in CSC-driven tumorigenesis, uncovering novel therapeutic avenues of using SPHK1-targeted therapy in the treatment of CSC-enriched refractory cancers.Ling-Wei HiiLing-Wei HiiFelicia Fei-Lei ChungChun-Wai MaiChun-Wai MaiPei Yuen NgChee-Onn LeongChee-Onn LeongFrontiers Media S.A.articlesphingosine kinasesphingosine-1-phosphatesphingosine-1-phosphate receptorbreast cancercancer stem cellssphingosine kinase inhibitorBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sphingosine kinase sphingosine-1-phosphate sphingosine-1-phosphate receptor breast cancer cancer stem cells sphingosine kinase inhibitor Biology (General) QH301-705.5
spellingShingle	sphingosine kinase sphingosine-1-phosphate sphingosine-1-phosphate receptor breast cancer cancer stem cells sphingosine kinase inhibitor Biology (General) QH301-705.5 Ling-Wei Hii Ling-Wei Hii Felicia Fei-Lei Chung Chun-Wai Mai Chun-Wai Mai Pei Yuen Ng Chee-Onn Leong Chee-Onn Leong Sphingosine Kinase 1 Signaling in Breast Cancer: A Potential Target to Tackle Breast Cancer Stem Cells
description	Sphingosine kinases (SPHKs) are conserved lipid enzymes that catalyze the formation of sphingosine-1-phosphate (S1P) through ATP-dependent phosphorylation of sphingosine. Two distinct SPHK isoforms, namely SPHK1 and SPHK2, have been identified to date, and the former has been implicated for its oncogenic roles in cancer development and progression. While SPHK1 signaling axis has been extensively studied in non-stem breast cancer cells, recent evidence has emerged to suggest a role of SPHK1 in regulating cancer stem cells (CSCs). With the clinical implications of CSCs in disease relapse and metastasis, it is believed that therapeutic approaches that can eradicate both non-stem cancer cells and CSCs could be a key to cancer cure. In this review, we first explore the oncogenic functions of sphingosine kinase 1 in human cancers and summarize current research findings of SPHK1 signaling with a focus on breast cancer. We also discuss the therapeutic potentials and perspectives of targeting SPHK1 signaling in breast cancer and cancer stem cells. We aim to offer new insights and inspire future studies looking further into the regulatory functions of SPHK1 in CSC-driven tumorigenesis, uncovering novel therapeutic avenues of using SPHK1-targeted therapy in the treatment of CSC-enriched refractory cancers.
format	article
author	Ling-Wei Hii Ling-Wei Hii Felicia Fei-Lei Chung Chun-Wai Mai Chun-Wai Mai Pei Yuen Ng Chee-Onn Leong Chee-Onn Leong
author_facet	Ling-Wei Hii Ling-Wei Hii Felicia Fei-Lei Chung Chun-Wai Mai Chun-Wai Mai Pei Yuen Ng Chee-Onn Leong Chee-Onn Leong
author_sort	Ling-Wei Hii
title	Sphingosine Kinase 1 Signaling in Breast Cancer: A Potential Target to Tackle Breast Cancer Stem Cells
title_short	Sphingosine Kinase 1 Signaling in Breast Cancer: A Potential Target to Tackle Breast Cancer Stem Cells
title_full	Sphingosine Kinase 1 Signaling in Breast Cancer: A Potential Target to Tackle Breast Cancer Stem Cells
title_fullStr	Sphingosine Kinase 1 Signaling in Breast Cancer: A Potential Target to Tackle Breast Cancer Stem Cells
title_full_unstemmed	Sphingosine Kinase 1 Signaling in Breast Cancer: A Potential Target to Tackle Breast Cancer Stem Cells
title_sort	sphingosine kinase 1 signaling in breast cancer: a potential target to tackle breast cancer stem cells
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b512e9fc0b7346868f266b6c6bee4419
work_keys_str_mv	AT lingweihii sphingosinekinase1signalinginbreastcancerapotentialtargettotacklebreastcancerstemcells AT lingweihii sphingosinekinase1signalinginbreastcancerapotentialtargettotacklebreastcancerstemcells AT feliciafeileichung sphingosinekinase1signalinginbreastcancerapotentialtargettotacklebreastcancerstemcells AT chunwaimai sphingosinekinase1signalinginbreastcancerapotentialtargettotacklebreastcancerstemcells AT chunwaimai sphingosinekinase1signalinginbreastcancerapotentialtargettotacklebreastcancerstemcells AT peiyuenng sphingosinekinase1signalinginbreastcancerapotentialtargettotacklebreastcancerstemcells AT cheeonnleong sphingosinekinase1signalinginbreastcancerapotentialtargettotacklebreastcancerstemcells AT cheeonnleong sphingosinekinase1signalinginbreastcancerapotentialtargettotacklebreastcancerstemcells
_version_	1718443032498405376

Sphingosine Kinase 1 Signaling in Breast Cancer: A Potential Target to Tackle Breast Cancer Stem Cells

Ejemplares similares