Reproductive and environmental exposures and the breast cancer risk in Taiwanese women

Abstract Breast cancer (BC) incidence is increasing around the globe, including in Taiwan, though the cause of the increasing incidence is less clear. We followed up 11,296 Taiwanese females who did not have BC at baseline, and ascertained new invasive BC (N = 351) through data linkage to the Nation...

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Autores principales:	Hui-Chen Wu, Hwai-I. Yang, Po-Han Lin, Chien-Jen Chen, Regina M. Santella, Mary Beth Terry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b515d2aee1bf4728a8994e301e450334
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spelling	oai:doaj.org-article:b515d2aee1bf4728a8994e301e4503342021-12-02T17:06:10ZReproductive and environmental exposures and the breast cancer risk in Taiwanese women10.1038/s41598-021-95290-22045-2322https://doaj.org/article/b515d2aee1bf4728a8994e301e4503342021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95290-2https://doaj.org/toc/2045-2322Abstract Breast cancer (BC) incidence is increasing around the globe, including in Taiwan, though the cause of the increasing incidence is less clear. We followed up 11,296 Taiwanese females who did not have BC at baseline, and ascertained new invasive BC (N = 351) through data linkage to the National Cancer Registry from 1991 to 2018 to examine whether reproductive, lifestyle and environmental risk factors including polycyclic aromatic hydrocarbons (PAH) were associated with BC risk. We conducted a nested case–control study using baseline blood available from a total of 305 women with BC and 598 women without BC matched on time in cohort. We examined the association of PAH-albumin adducts and BC risk using conditional logistic regression models. Age at menarche (HR 0.6 (95% CI 0.5–0.9) for ≥ 15 vs. < 13 years) and multiparity were associated with BC risk (HR 2.0 (95% CI 1.4–2.8), 2.8 (1.9–4.2), and 2.4 (1.0–5.0) for 3–4, 1–2 and 0 live birth, compared with women ≥ 5 births). PAH-albumin adducts were not associated with BC risk. Given the increasing BC incidence in Taiwan, there is a need to identify environmental factors that are important to this population.Hui-Chen WuHwai-I. YangPo-Han LinChien-Jen ChenRegina M. SantellaMary Beth TerryNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hui-Chen Wu Hwai-I. Yang Po-Han Lin Chien-Jen Chen Regina M. Santella Mary Beth Terry Reproductive and environmental exposures and the breast cancer risk in Taiwanese women
description	Abstract Breast cancer (BC) incidence is increasing around the globe, including in Taiwan, though the cause of the increasing incidence is less clear. We followed up 11,296 Taiwanese females who did not have BC at baseline, and ascertained new invasive BC (N = 351) through data linkage to the National Cancer Registry from 1991 to 2018 to examine whether reproductive, lifestyle and environmental risk factors including polycyclic aromatic hydrocarbons (PAH) were associated with BC risk. We conducted a nested case–control study using baseline blood available from a total of 305 women with BC and 598 women without BC matched on time in cohort. We examined the association of PAH-albumin adducts and BC risk using conditional logistic regression models. Age at menarche (HR 0.6 (95% CI 0.5–0.9) for ≥ 15 vs. < 13 years) and multiparity were associated with BC risk (HR 2.0 (95% CI 1.4–2.8), 2.8 (1.9–4.2), and 2.4 (1.0–5.0) for 3–4, 1–2 and 0 live birth, compared with women ≥ 5 births). PAH-albumin adducts were not associated with BC risk. Given the increasing BC incidence in Taiwan, there is a need to identify environmental factors that are important to this population.
format	article
author	Hui-Chen Wu Hwai-I. Yang Po-Han Lin Chien-Jen Chen Regina M. Santella Mary Beth Terry
author_facet	Hui-Chen Wu Hwai-I. Yang Po-Han Lin Chien-Jen Chen Regina M. Santella Mary Beth Terry
author_sort	Hui-Chen Wu
title	Reproductive and environmental exposures and the breast cancer risk in Taiwanese women
title_short	Reproductive and environmental exposures and the breast cancer risk in Taiwanese women
title_full	Reproductive and environmental exposures and the breast cancer risk in Taiwanese women
title_fullStr	Reproductive and environmental exposures and the breast cancer risk in Taiwanese women
title_full_unstemmed	Reproductive and environmental exposures and the breast cancer risk in Taiwanese women
title_sort	reproductive and environmental exposures and the breast cancer risk in taiwanese women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b515d2aee1bf4728a8994e301e450334
work_keys_str_mv	AT huichenwu reproductiveandenvironmentalexposuresandthebreastcancerriskintaiwanesewomen AT hwaiiyang reproductiveandenvironmentalexposuresandthebreastcancerriskintaiwanesewomen AT pohanlin reproductiveandenvironmentalexposuresandthebreastcancerriskintaiwanesewomen AT chienjenchen reproductiveandenvironmentalexposuresandthebreastcancerriskintaiwanesewomen AT reginamsantella reproductiveandenvironmentalexposuresandthebreastcancerriskintaiwanesewomen AT marybethterry reproductiveandenvironmentalexposuresandthebreastcancerriskintaiwanesewomen
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Reproductive and environmental exposures and the breast cancer risk in Taiwanese women

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