MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration

Mitochondrial calcium uptake is a highly regulated process, and calcium overload can lead to cell death. Here, using knockout mouse model, the authors show that the mitochondrial calcium uniporter (MCU) regulator MICU1 is needed to prevent calcium overload and promotes survival under liver regenerat...

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Autores principales: Anil Noronha Antony, Melanie Paillard, Cynthia Moffat, Egle Juskeviciute, Jason Correnti, Brad Bolon, Emanuel Rubin, György Csordás, Erin L. Seifert, Jan B. Hoek, György Hajnóczky
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/b517a4d3792f4bae85feef95db236c74
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spelling oai:doaj.org-article:b517a4d3792f4bae85feef95db236c742021-12-02T16:49:25ZMICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration10.1038/ncomms109552041-1723https://doaj.org/article/b517a4d3792f4bae85feef95db236c742016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10955https://doaj.org/toc/2041-1723Mitochondrial calcium uptake is a highly regulated process, and calcium overload can lead to cell death. Here, using knockout mouse model, the authors show that the mitochondrial calcium uniporter (MCU) regulator MICU1 is needed to prevent calcium overload and promotes survival under liver regeneration and postnatal adaptation-associated stress.Anil Noronha AntonyMelanie PaillardCynthia MoffatEgle JuskeviciuteJason CorrentiBrad BolonEmanuel RubinGyörgy CsordásErin L. SeifertJan B. HoekGyörgy HajnóczkyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Anil Noronha Antony
Melanie Paillard
Cynthia Moffat
Egle Juskeviciute
Jason Correnti
Brad Bolon
Emanuel Rubin
György Csordás
Erin L. Seifert
Jan B. Hoek
György Hajnóczky
MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration
description Mitochondrial calcium uptake is a highly regulated process, and calcium overload can lead to cell death. Here, using knockout mouse model, the authors show that the mitochondrial calcium uniporter (MCU) regulator MICU1 is needed to prevent calcium overload and promotes survival under liver regeneration and postnatal adaptation-associated stress.
format article
author Anil Noronha Antony
Melanie Paillard
Cynthia Moffat
Egle Juskeviciute
Jason Correnti
Brad Bolon
Emanuel Rubin
György Csordás
Erin L. Seifert
Jan B. Hoek
György Hajnóczky
author_facet Anil Noronha Antony
Melanie Paillard
Cynthia Moffat
Egle Juskeviciute
Jason Correnti
Brad Bolon
Emanuel Rubin
György Csordás
Erin L. Seifert
Jan B. Hoek
György Hajnóczky
author_sort Anil Noronha Antony
title MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration
title_short MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration
title_full MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration
title_fullStr MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration
title_full_unstemmed MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration
title_sort micu1 regulation of mitochondrial ca2+ uptake dictates survival and tissue regeneration
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/b517a4d3792f4bae85feef95db236c74
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