MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration
Mitochondrial calcium uptake is a highly regulated process, and calcium overload can lead to cell death. Here, using knockout mouse model, the authors show that the mitochondrial calcium uniporter (MCU) regulator MICU1 is needed to prevent calcium overload and promotes survival under liver regenerat...
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Nature Portfolio
2016
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oai:doaj.org-article:b517a4d3792f4bae85feef95db236c742021-12-02T16:49:25ZMICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration10.1038/ncomms109552041-1723https://doaj.org/article/b517a4d3792f4bae85feef95db236c742016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10955https://doaj.org/toc/2041-1723Mitochondrial calcium uptake is a highly regulated process, and calcium overload can lead to cell death. Here, using knockout mouse model, the authors show that the mitochondrial calcium uniporter (MCU) regulator MICU1 is needed to prevent calcium overload and promotes survival under liver regeneration and postnatal adaptation-associated stress.Anil Noronha AntonyMelanie PaillardCynthia MoffatEgle JuskeviciuteJason CorrentiBrad BolonEmanuel RubinGyörgy CsordásErin L. SeifertJan B. HoekGyörgy HajnóczkyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016) |
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Science Q Anil Noronha Antony Melanie Paillard Cynthia Moffat Egle Juskeviciute Jason Correnti Brad Bolon Emanuel Rubin György Csordás Erin L. Seifert Jan B. Hoek György Hajnóczky MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration |
description |
Mitochondrial calcium uptake is a highly regulated process, and calcium overload can lead to cell death. Here, using knockout mouse model, the authors show that the mitochondrial calcium uniporter (MCU) regulator MICU1 is needed to prevent calcium overload and promotes survival under liver regeneration and postnatal adaptation-associated stress. |
format |
article |
author |
Anil Noronha Antony Melanie Paillard Cynthia Moffat Egle Juskeviciute Jason Correnti Brad Bolon Emanuel Rubin György Csordás Erin L. Seifert Jan B. Hoek György Hajnóczky |
author_facet |
Anil Noronha Antony Melanie Paillard Cynthia Moffat Egle Juskeviciute Jason Correnti Brad Bolon Emanuel Rubin György Csordás Erin L. Seifert Jan B. Hoek György Hajnóczky |
author_sort |
Anil Noronha Antony |
title |
MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration |
title_short |
MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration |
title_full |
MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration |
title_fullStr |
MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration |
title_full_unstemmed |
MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration |
title_sort |
micu1 regulation of mitochondrial ca2+ uptake dictates survival and tissue regeneration |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/b517a4d3792f4bae85feef95db236c74 |
work_keys_str_mv |
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