MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration

MICU1 regulation of mitochondrial Ca2+ uptake dictates survival and tissue regeneration

Mitochondrial calcium uptake is a highly regulated process, and calcium overload can lead to cell death. Here, using knockout mouse model, the authors show that the mitochondrial calcium uniporter (MCU) regulator MICU1 is needed to prevent calcium overload and promotes survival under liver regenerat...

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Autores principales: Anil Noronha Antony, Melanie Paillard, Cynthia Moffat, Egle Juskeviciute, Jason Correnti, Brad Bolon, Emanuel Rubin, György Csordás, Erin L. Seifert, Jan B. Hoek, György Hajnóczky
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/b517a4d3792f4bae85feef95db236c74
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