Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction

There is accumulating evidence highlighting a close relationship between inflammation and coronary microvascular dysfunction (CMD) in various experimental and clinical settings, with major clinical implications. Chronic low-grade vascular inflammation plays important roles in the underlying mechanis...

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Autores principales:	Shigeo Godo, Jun Takahashi, Satoshi Yasuda, Hiroaki Shimokawa
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/b51c21286a304a6dbf9f2eaad0b95cbd
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spelling	oai:doaj.org-article:b51c21286a304a6dbf9f2eaad0b95cbd2021-12-04T16:04:11ZRole of Inflammation in Coronary Epicardial and Microvascular Dysfunction10.15420/ecr.2020.471758-37641758-3756https://doaj.org/article/b51c21286a304a6dbf9f2eaad0b95cbd2021-03-01T00:00:00Zhttps://www.ecrjournal.com/articleindex/ecr.2020.47https://doaj.org/toc/1758-3756https://doaj.org/toc/1758-3764There is accumulating evidence highlighting a close relationship between inflammation and coronary microvascular dysfunction (CMD) in various experimental and clinical settings, with major clinical implications. Chronic low-grade vascular inflammation plays important roles in the underlying mechanisms behind CMD, especially in patients with coronary artery disease, obesity, heart failure with preserved ejection fraction and chronic inflammatory rheumatoid diseases. The central mechanisms of coronary vasomotion abnormalities comprise enhanced coronary vasoconstrictor reactivity, reduced endothelium-dependent and -independent coronary vasodilator capacity and increased coronary microvascular resistance, where inflammatory mediators and responses are substantially involved. How to modulate CMD to improve clinical outcomes of patients with the disorder and whether CMD management by targeting inflammatory responses can benefit patients remain challenging questions in need of further research. This review provides a concise overview of the current knowledge of the involvement of inflammation in the pathophysiology and molecular mechanisms of CMD from bench to bedside.Shigeo GodoJun TakahashiSatoshi YasudaHiroaki ShimokawaRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENEuropean Cardiology Review , Vol 16, Iss , Pp - (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Shigeo Godo Jun Takahashi Satoshi Yasuda Hiroaki Shimokawa Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction
description	There is accumulating evidence highlighting a close relationship between inflammation and coronary microvascular dysfunction (CMD) in various experimental and clinical settings, with major clinical implications. Chronic low-grade vascular inflammation plays important roles in the underlying mechanisms behind CMD, especially in patients with coronary artery disease, obesity, heart failure with preserved ejection fraction and chronic inflammatory rheumatoid diseases. The central mechanisms of coronary vasomotion abnormalities comprise enhanced coronary vasoconstrictor reactivity, reduced endothelium-dependent and -independent coronary vasodilator capacity and increased coronary microvascular resistance, where inflammatory mediators and responses are substantially involved. How to modulate CMD to improve clinical outcomes of patients with the disorder and whether CMD management by targeting inflammatory responses can benefit patients remain challenging questions in need of further research. This review provides a concise overview of the current knowledge of the involvement of inflammation in the pathophysiology and molecular mechanisms of CMD from bench to bedside.
format	article
author	Shigeo Godo Jun Takahashi Satoshi Yasuda Hiroaki Shimokawa
author_facet	Shigeo Godo Jun Takahashi Satoshi Yasuda Hiroaki Shimokawa
author_sort	Shigeo Godo
title	Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction
title_short	Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction
title_full	Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction
title_fullStr	Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction
title_full_unstemmed	Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction
title_sort	role of inflammation in coronary epicardial and microvascular dysfunction
publisher	Radcliffe Medical Media
publishDate	2021
url	https://doaj.org/article/b51c21286a304a6dbf9f2eaad0b95cbd
work_keys_str_mv	AT shigeogodo roleofinflammationincoronaryepicardialandmicrovasculardysfunction AT juntakahashi roleofinflammationincoronaryepicardialandmicrovasculardysfunction AT satoshiyasuda roleofinflammationincoronaryepicardialandmicrovasculardysfunction AT hiroakishimokawa roleofinflammationincoronaryepicardialandmicrovasculardysfunction
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Role of Inflammation in Coronary Epicardial and Microvascular Dysfunction

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