Phosphorylation modifies the molecular stability of β-amyloid deposits
Protein aggregation plays a crucial role in several neurodegenerative diseases. Here the authors demonstrate that phosphorylation of β-amyloid aggregates—the pathological hallmark of Alzheimer's disease—can change the molecular properties of aggregates, suggesting how phosphorylation contribute...
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Nature Portfolio
2016
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oai:doaj.org-article:b51e7f2b30e242a2be7281a13feadd102021-12-02T17:32:06ZPhosphorylation modifies the molecular stability of β-amyloid deposits10.1038/ncomms113592041-1723https://doaj.org/article/b51e7f2b30e242a2be7281a13feadd102016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11359https://doaj.org/toc/2041-1723Protein aggregation plays a crucial role in several neurodegenerative diseases. Here the authors demonstrate that phosphorylation of β-amyloid aggregates—the pathological hallmark of Alzheimer's disease—can change the molecular properties of aggregates, suggesting how phosphorylation contributes to disease progression.Nasrollah Rezaei-GhalehMehriar AmininasabSathish KumarJochen WalterMarkus ZweckstetterNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016) |
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Science Q Nasrollah Rezaei-Ghaleh Mehriar Amininasab Sathish Kumar Jochen Walter Markus Zweckstetter Phosphorylation modifies the molecular stability of β-amyloid deposits |
description |
Protein aggregation plays a crucial role in several neurodegenerative diseases. Here the authors demonstrate that phosphorylation of β-amyloid aggregates—the pathological hallmark of Alzheimer's disease—can change the molecular properties of aggregates, suggesting how phosphorylation contributes to disease progression. |
format |
article |
author |
Nasrollah Rezaei-Ghaleh Mehriar Amininasab Sathish Kumar Jochen Walter Markus Zweckstetter |
author_facet |
Nasrollah Rezaei-Ghaleh Mehriar Amininasab Sathish Kumar Jochen Walter Markus Zweckstetter |
author_sort |
Nasrollah Rezaei-Ghaleh |
title |
Phosphorylation modifies the molecular stability of β-amyloid deposits |
title_short |
Phosphorylation modifies the molecular stability of β-amyloid deposits |
title_full |
Phosphorylation modifies the molecular stability of β-amyloid deposits |
title_fullStr |
Phosphorylation modifies the molecular stability of β-amyloid deposits |
title_full_unstemmed |
Phosphorylation modifies the molecular stability of β-amyloid deposits |
title_sort |
phosphorylation modifies the molecular stability of β-amyloid deposits |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/b51e7f2b30e242a2be7281a13feadd10 |
work_keys_str_mv |
AT nasrollahrezaeighaleh phosphorylationmodifiesthemolecularstabilityofbamyloiddeposits AT mehriaramininasab phosphorylationmodifiesthemolecularstabilityofbamyloiddeposits AT sathishkumar phosphorylationmodifiesthemolecularstabilityofbamyloiddeposits AT jochenwalter phosphorylationmodifiesthemolecularstabilityofbamyloiddeposits AT markuszweckstetter phosphorylationmodifiesthemolecularstabilityofbamyloiddeposits |
_version_ |
1718380391401783296 |