14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

Platelets express negatively charged phosphatidylserine (PS) on their plasma membrane when propagating coagulation within a developing thrombus. Here the authors show that an adaptor protein 14-3-3 regulates mitochondrial function and PS exposure and thus platelet procoagulant activity, promising a...

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Autores principales: Simone M. Schoenwaelder, Roxane Darbousset, Susan L. Cranmer, Hayley S. Ramshaw, Stephanie L. Orive, Sharelle Sturgeon, Yuping Yuan, Yu Yao, James R. Krycer, Joanna Woodcock, Jessica Maclean, Stuart Pitson, Zhaohua Zheng, Darren C. Henstridge, Dianne van der Wal, Elizabeth E. Gardiner, Michael C. Berndt, Robert K. Andrews, David E. James, Angel F. Lopez, Shaun P. Jackson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/b523399dd63e458a9df758471882f328
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spelling oai:doaj.org-article:b523399dd63e458a9df758471882f3282021-12-02T14:38:34Z14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function10.1038/ncomms128622041-1723https://doaj.org/article/b523399dd63e458a9df758471882f3282016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12862https://doaj.org/toc/2041-1723Platelets express negatively charged phosphatidylserine (PS) on their plasma membrane when propagating coagulation within a developing thrombus. Here the authors show that an adaptor protein 14-3-3 regulates mitochondrial function and PS exposure and thus platelet procoagulant activity, promising a new therapy to reduce thrombosis.Simone M. SchoenwaelderRoxane DarboussetSusan L. CranmerHayley S. RamshawStephanie L. OriveSharelle SturgeonYuping YuanYu YaoJames R. KrycerJoanna WoodcockJessica MacleanStuart PitsonZhaohua ZhengDarren C. HenstridgeDianne van der WalElizabeth E. GardinerMichael C. BerndtRobert K. AndrewsDavid E. JamesAngel F. LopezShaun P. JacksonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Simone M. Schoenwaelder
Roxane Darbousset
Susan L. Cranmer
Hayley S. Ramshaw
Stephanie L. Orive
Sharelle Sturgeon
Yuping Yuan
Yu Yao
James R. Krycer
Joanna Woodcock
Jessica Maclean
Stuart Pitson
Zhaohua Zheng
Darren C. Henstridge
Dianne van der Wal
Elizabeth E. Gardiner
Michael C. Berndt
Robert K. Andrews
David E. James
Angel F. Lopez
Shaun P. Jackson
14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
description Platelets express negatively charged phosphatidylserine (PS) on their plasma membrane when propagating coagulation within a developing thrombus. Here the authors show that an adaptor protein 14-3-3 regulates mitochondrial function and PS exposure and thus platelet procoagulant activity, promising a new therapy to reduce thrombosis.
format article
author Simone M. Schoenwaelder
Roxane Darbousset
Susan L. Cranmer
Hayley S. Ramshaw
Stephanie L. Orive
Sharelle Sturgeon
Yuping Yuan
Yu Yao
James R. Krycer
Joanna Woodcock
Jessica Maclean
Stuart Pitson
Zhaohua Zheng
Darren C. Henstridge
Dianne van der Wal
Elizabeth E. Gardiner
Michael C. Berndt
Robert K. Andrews
David E. James
Angel F. Lopez
Shaun P. Jackson
author_facet Simone M. Schoenwaelder
Roxane Darbousset
Susan L. Cranmer
Hayley S. Ramshaw
Stephanie L. Orive
Sharelle Sturgeon
Yuping Yuan
Yu Yao
James R. Krycer
Joanna Woodcock
Jessica Maclean
Stuart Pitson
Zhaohua Zheng
Darren C. Henstridge
Dianne van der Wal
Elizabeth E. Gardiner
Michael C. Berndt
Robert K. Andrews
David E. James
Angel F. Lopez
Shaun P. Jackson
author_sort Simone M. Schoenwaelder
title 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
title_short 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
title_full 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
title_fullStr 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
title_full_unstemmed 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
title_sort 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/b523399dd63e458a9df758471882f328
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