Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery

Mitochondria are key targets for photothermal and photodynamic treatment for cancer but delivery of therapeutics to these organelles remains a challenge. In this study, authors develop a mitochondrial targeted liposomal delivery platform using a dendritic peptide moiety as a mitochondria targeting m...

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Autores principales:	Lei Jiang, Sensen Zhou, Xiaoke Zhang, Cheng Li, Shilu Ji, Hui Mao, Xiqun Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b523e89cd2e14554af8523e7a2b39849
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spelling	oai:doaj.org-article:b523e89cd2e14554af8523e7a2b398492021-12-02T13:39:46ZMitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery10.1038/s41467-021-22594-22041-1723https://doaj.org/article/b523e89cd2e14554af8523e7a2b398492021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22594-2https://doaj.org/toc/2041-1723Mitochondria are key targets for photothermal and photodynamic treatment for cancer but delivery of therapeutics to these organelles remains a challenge. In this study, authors develop a mitochondrial targeted liposomal delivery platform using a dendritic peptide moiety as a mitochondria targeting moiety and demonstrate its targeting and antitumour efficacy in a mouse model of breast cancer.Lei JiangSensen ZhouXiaoke ZhangCheng LiShilu JiHui MaoXiqun JiangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Jiang Sensen Zhou Xiaoke Zhang Cheng Li Shilu Ji Hui Mao Xiqun Jiang Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery
description	Mitochondria are key targets for photothermal and photodynamic treatment for cancer but delivery of therapeutics to these organelles remains a challenge. In this study, authors develop a mitochondrial targeted liposomal delivery platform using a dendritic peptide moiety as a mitochondria targeting moiety and demonstrate its targeting and antitumour efficacy in a mouse model of breast cancer.
format	article
author	Lei Jiang Sensen Zhou Xiaoke Zhang Cheng Li Shilu Ji Hui Mao Xiqun Jiang
author_facet	Lei Jiang Sensen Zhou Xiaoke Zhang Cheng Li Shilu Ji Hui Mao Xiqun Jiang
author_sort	Lei Jiang
title	Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery
title_short	Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery
title_full	Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery
title_fullStr	Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery
title_full_unstemmed	Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery
title_sort	mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b523e89cd2e14554af8523e7a2b39849
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Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery

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