Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

TREM2 is a genetic risk factor for Alzheimer’s disease, and soluble TREM2 (sTREM2) in the CSF correlates with AD progression. Here the authors study the role of sTREM2 in a mouse model of Alzheimer’s disease, and find it reduces amyloid accumulation and increases the numbers of plaque-associated mic...

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Autores principales:	Li Zhong, Ying Xu, Rengong Zhuo, Tingting Wang, Kai Wang, Ruizhi Huang, Daxin Wang, Yue Gao, Yifei Zhu, Xuan Sheng, Kai Chen, Na Wang, Lin Zhu, Dan Can, Yuka Marten, Mitsuru Shinohara, Chia-Chen Liu, Dan Du, Hao Sun, Lei Wen, Huaxi Xu, Guojun Bu, Xiao-Fen Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b52435dfcf7a4d5aa13e0d196ad259a1
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spelling	oai:doaj.org-article:b52435dfcf7a4d5aa13e0d196ad259a12021-12-02T16:57:30ZSoluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model10.1038/s41467-019-09118-92041-1723https://doaj.org/article/b52435dfcf7a4d5aa13e0d196ad259a12019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09118-9https://doaj.org/toc/2041-1723TREM2 is a genetic risk factor for Alzheimer’s disease, and soluble TREM2 (sTREM2) in the CSF correlates with AD progression. Here the authors study the role of sTREM2 in a mouse model of Alzheimer’s disease, and find it reduces amyloid accumulation and increases the numbers of plaque-associated microglia which correlates with improved behavioural function in the mice.Li ZhongYing XuRengong ZhuoTingting WangKai WangRuizhi HuangDaxin WangYue GaoYifei ZhuXuan ShengKai ChenNa WangLin ZhuDan CanYuka MartenMitsuru ShinoharaChia-Chen LiuDan DuHao SunLei WenHuaxi XuGuojun BuXiao-Fen ChenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Li Zhong Ying Xu Rengong Zhuo Tingting Wang Kai Wang Ruizhi Huang Daxin Wang Yue Gao Yifei Zhu Xuan Sheng Kai Chen Na Wang Lin Zhu Dan Can Yuka Marten Mitsuru Shinohara Chia-Chen Liu Dan Du Hao Sun Lei Wen Huaxi Xu Guojun Bu Xiao-Fen Chen Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
description	TREM2 is a genetic risk factor for Alzheimer’s disease, and soluble TREM2 (sTREM2) in the CSF correlates with AD progression. Here the authors study the role of sTREM2 in a mouse model of Alzheimer’s disease, and find it reduces amyloid accumulation and increases the numbers of plaque-associated microglia which correlates with improved behavioural function in the mice.
format	article
author	Li Zhong Ying Xu Rengong Zhuo Tingting Wang Kai Wang Ruizhi Huang Daxin Wang Yue Gao Yifei Zhu Xuan Sheng Kai Chen Na Wang Lin Zhu Dan Can Yuka Marten Mitsuru Shinohara Chia-Chen Liu Dan Du Hao Sun Lei Wen Huaxi Xu Guojun Bu Xiao-Fen Chen
author_facet	Li Zhong Ying Xu Rengong Zhuo Tingting Wang Kai Wang Ruizhi Huang Daxin Wang Yue Gao Yifei Zhu Xuan Sheng Kai Chen Na Wang Lin Zhu Dan Can Yuka Marten Mitsuru Shinohara Chia-Chen Liu Dan Du Hao Sun Lei Wen Huaxi Xu Guojun Bu Xiao-Fen Chen
author_sort	Li Zhong
title	Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
title_short	Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
title_full	Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
title_fullStr	Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
title_full_unstemmed	Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
title_sort	soluble trem2 ameliorates pathological phenotypes by modulating microglial functions in an alzheimer’s disease model
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b52435dfcf7a4d5aa13e0d196ad259a1
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Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

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