WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis

WNTs can signal over long distances but how this arises in the brain is unclear. Here, the authors show that WNT5A is secreted from the choroid plexus of the developing hindbrain (but not the telencephalon) and transported in the CSF with lipoprotein particles in order to control cerebellar morphoge...

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Autores principales:	Karol Kaiser, Daniel Gyllborg, Jan Procházka, Alena Salašová, Petra Kompaníková, Francisco Lamus Molina, Rocio Laguna-Goya, Tomasz Radaszkiewicz, Jakub Harnoš, Michaela Procházková, David Potěšil, Roger A. Barker, Ángel Gato Casado, Zbyněk Zdráhal, Radislav Sedláček, Ernest Arenas, J. Carlos Villaescusa, Vítězslav Bryja
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b5243ecd5bb74a85a22885abf4c818ed
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spelling	oai:doaj.org-article:b5243ecd5bb74a85a22885abf4c818ed2021-12-02T17:02:01ZWNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis10.1038/s41467-019-09298-42041-1723https://doaj.org/article/b5243ecd5bb74a85a22885abf4c818ed2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09298-4https://doaj.org/toc/2041-1723WNTs can signal over long distances but how this arises in the brain is unclear. Here, the authors show that WNT5A is secreted from the choroid plexus of the developing hindbrain (but not the telencephalon) and transported in the CSF with lipoprotein particles in order to control cerebellar morphogenesis.Karol KaiserDaniel GyllborgJan ProcházkaAlena SalašováPetra KompaníkováFrancisco Lamus MolinaRocio Laguna-GoyaTomasz RadaszkiewiczJakub HarnošMichaela ProcházkováDavid PotěšilRoger A. BarkerÁngel Gato CasadoZbyněk ZdráhalRadislav SedláčekErnest ArenasJ. Carlos VillaescusaVítězslav BryjaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karol Kaiser Daniel Gyllborg Jan Procházka Alena Salašová Petra Kompaníková Francisco Lamus Molina Rocio Laguna-Goya Tomasz Radaszkiewicz Jakub Harnoš Michaela Procházková David Potěšil Roger A. Barker Ángel Gato Casado Zbyněk Zdráhal Radislav Sedláček Ernest Arenas J. Carlos Villaescusa Vítězslav Bryja WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis
description	WNTs can signal over long distances but how this arises in the brain is unclear. Here, the authors show that WNT5A is secreted from the choroid plexus of the developing hindbrain (but not the telencephalon) and transported in the CSF with lipoprotein particles in order to control cerebellar morphogenesis.
format	article
author	Karol Kaiser Daniel Gyllborg Jan Procházka Alena Salašová Petra Kompaníková Francisco Lamus Molina Rocio Laguna-Goya Tomasz Radaszkiewicz Jakub Harnoš Michaela Procházková David Potěšil Roger A. Barker Ángel Gato Casado Zbyněk Zdráhal Radislav Sedláček Ernest Arenas J. Carlos Villaescusa Vítězslav Bryja
author_facet	Karol Kaiser Daniel Gyllborg Jan Procházka Alena Salašová Petra Kompaníková Francisco Lamus Molina Rocio Laguna-Goya Tomasz Radaszkiewicz Jakub Harnoš Michaela Procházková David Potěšil Roger A. Barker Ángel Gato Casado Zbyněk Zdráhal Radislav Sedláček Ernest Arenas J. Carlos Villaescusa Vítězslav Bryja
author_sort	Karol Kaiser
title	WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis
title_short	WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis
title_full	WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis
title_fullStr	WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis
title_full_unstemmed	WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis
title_sort	wnt5a is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b5243ecd5bb74a85a22885abf4c818ed
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WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis

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