Nanoparticle-based drug delivery to improve the efficacy of antiretroviral therapy in the central nervous system

Maria João Gomes,1 José das Neves,1,2 Bruno Sarmento1,2 1Instituto de Engenharia Biomédica (INEB), Porto, Portugal; 2Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Sa&ua...

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Autores principales:	Gomes MJ, das Neves J, Sarmento B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b52475b44fcb40cdb2ab4930af5b2d8f
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spelling	oai:doaj.org-article:b52475b44fcb40cdb2ab4930af5b2d8f2021-12-02T08:07:44ZNanoparticle-based drug delivery to improve the efficacy of antiretroviral therapy in the central nervous system1178-2013https://doaj.org/article/b52475b44fcb40cdb2ab4930af5b2d8f2014-04-01T00:00:00Zhttp://www.dovepress.com/nanoparticle-based-drug-delivery-to-improve-the-efficacy-of-antiretrov-a16372https://doaj.org/toc/1178-2013 Maria João Gomes,1 José das Neves,1,2 Bruno Sarmento1,2 1Instituto de Engenharia Biomédica (INEB), Porto, Portugal; 2Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde (IINFACTS), Instituto Superior de Ciências da Saúde-Norte, CESPU, Gandra, Portugal Abstract: Antiretroviral drug therapy plays a cornerstone role in the treatment of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome patients. Despite obvious advances over the past 3 decades, new approaches toward improved management of infected individuals are still required. Drug distribution to the central nervous system (CNS) is required in order to limit and control viral infection, but the presence of natural barrier structures, in particular the blood–brain barrier, strongly limits the perfusion of anti-HIV compounds into this anatomical site. Nanotechnology-based approaches may help providing solutions for antiretroviral drug delivery to the CNS by potentially prolonging systemic drug circulation, increasing the crossing and reducing the efflux of active compounds at the blood–brain barrier, and providing cell/tissue-targeting and intracellular drug delivery. After an initial overview on the basic features of HIV infection of the CNS and barriers to active compound delivery to this anatomical site, this review focuses on recent strategies based on antiretroviral drug-loaded solid nanoparticles and drug nanosuspensions for the potential management of HIV infection of the CNS. Keywords: HIV/AIDS, blood–brain barrier, protease inhibitors, efflux transporters, drug targetingGomes MJdas Neves JSarmento BDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 1757-1769 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Gomes MJ das Neves J Sarmento B Nanoparticle-based drug delivery to improve the efficacy of antiretroviral therapy in the central nervous system
description	Maria João Gomes,1 José das Neves,1,2 Bruno Sarmento1,2 1Instituto de Engenharia Biomédica (INEB), Porto, Portugal; 2Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde (IINFACTS), Instituto Superior de Ciências da Saúde-Norte, CESPU, Gandra, Portugal Abstract: Antiretroviral drug therapy plays a cornerstone role in the treatment of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome patients. Despite obvious advances over the past 3 decades, new approaches toward improved management of infected individuals are still required. Drug distribution to the central nervous system (CNS) is required in order to limit and control viral infection, but the presence of natural barrier structures, in particular the blood–brain barrier, strongly limits the perfusion of anti-HIV compounds into this anatomical site. Nanotechnology-based approaches may help providing solutions for antiretroviral drug delivery to the CNS by potentially prolonging systemic drug circulation, increasing the crossing and reducing the efflux of active compounds at the blood–brain barrier, and providing cell/tissue-targeting and intracellular drug delivery. After an initial overview on the basic features of HIV infection of the CNS and barriers to active compound delivery to this anatomical site, this review focuses on recent strategies based on antiretroviral drug-loaded solid nanoparticles and drug nanosuspensions for the potential management of HIV infection of the CNS. Keywords: HIV/AIDS, blood–brain barrier, protease inhibitors, efflux transporters, drug targeting
format	article
author	Gomes MJ das Neves J Sarmento B
author_facet	Gomes MJ das Neves J Sarmento B
author_sort	Gomes MJ
title	Nanoparticle-based drug delivery to improve the efficacy of antiretroviral therapy in the central nervous system
title_short	Nanoparticle-based drug delivery to improve the efficacy of antiretroviral therapy in the central nervous system
title_full	Nanoparticle-based drug delivery to improve the efficacy of antiretroviral therapy in the central nervous system
title_fullStr	Nanoparticle-based drug delivery to improve the efficacy of antiretroviral therapy in the central nervous system
title_full_unstemmed	Nanoparticle-based drug delivery to improve the efficacy of antiretroviral therapy in the central nervous system
title_sort	nanoparticle-based drug delivery to improve the efficacy of antiretroviral therapy in the central nervous system
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/b52475b44fcb40cdb2ab4930af5b2d8f
work_keys_str_mv	AT gomesmj nanoparticlebaseddrugdeliverytoimprovetheefficacyofantiretroviraltherapyinthecentralnervoussystem AT dasnevesj nanoparticlebaseddrugdeliverytoimprovetheefficacyofantiretroviraltherapyinthecentralnervoussystem AT sarmentob nanoparticlebaseddrugdeliverytoimprovetheefficacyofantiretroviraltherapyinthecentralnervoussystem
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Nanoparticle-based drug delivery to improve the efficacy of antiretroviral therapy in the central nervous system

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