A single Gal4-like transcription factor activates the Crabtree effect in Komagataella phaffii

Aerobic ethanol production, a phenomenon referred as Crabtree effect, allows yeast to outcompete other microorganisms in sugar rich environments. Here, the authors show that overexpression of a Gal4-like transcription factor can transform Komagataella phaffii from Crabtree effect negative to positiv...

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Autores principales: Özge Ata, Corinna Rebnegger, Nadine E. Tatto, Minoska Valli, Teresa Mairinger, Stephan Hann, Matthias G. Steiger, Pınar Çalık, Diethard Mattanovich
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/b5356eee23814a6a86e92955ca493d85
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Sumario:Aerobic ethanol production, a phenomenon referred as Crabtree effect, allows yeast to outcompete other microorganisms in sugar rich environments. Here, the authors show that overexpression of a Gal4-like transcription factor can transform Komagataella phaffii from Crabtree effect negative to positive.