Cytotoxic effects of curcumin in osteosarcoma cells

JM Moran, FJ Rodriguez-Velasco, R Roncero-Martin, V Vera, JD Pedrera-Zamorano Metabolic Bone Diseases Research Group, University of Extremadura, Cáceres, SpainWe read with interest the results of the study from Chang et al1 in the International Journal of Nanomedicine. This article show...

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Autores principales:	Moran JM, Rodriguez-Velasco FJ, Roncero-Martin R, Vera V, Pedrera-Zamorano JD
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b536de76961c43f1a6af50e1df4f055a
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spelling	oai:doaj.org-article:b536de76961c43f1a6af50e1df4f055a2021-12-02T05:02:15ZCytotoxic effects of curcumin in osteosarcoma cells1178-2013https://doaj.org/article/b536de76961c43f1a6af50e1df4f055a2014-11-01T00:00:00Zhttp://www.dovepress.com/cytotoxic-effects-of-curcumin-in-osteosarcoma-cells-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 JM Moran, FJ Rodriguez-Velasco, R Roncero-Martin, V Vera, JD Pedrera-Zamorano Metabolic Bone Diseases Research Group, University of Extremadura, Cáceres, SpainWe read with interest the results of the study from Chang et al1 in the International Journal of Nanomedicine. This article shows that curcumin (diferuloymethane), a phenolic compound extracted from the natural plant Curcuma longa L., exerts higher cytotoxicity in osteosarcoma MG-63 cells than in healthy human osteoblasts. Based on the dosages provided by the authors it is hypothesized that with the appropriate drug carriers, curcumin could be delivered to bone tumors and selectively kill osteosarcoma cells without harming healthy osteoblasts. This hypothesis is based in the data provided that claims the dose needed to exert a significant cytotoxicity on osteosarcoma cells was much lower than that needed to exert the same effect on healthy human osteoblasts. The topic of this study is of importance for both cancer and metabolic bone disease fields, we appreciate the methodology of the study, nevertheless we believe that the hypothesis formulated by the authors and their conclusion deserves further comment.View original paper by Chang and colleagues.Moran JMRodriguez-Velasco FJRoncero-Martin RVera VPedrera-Zamorano JDDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 5273-5275 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Moran JM Rodriguez-Velasco FJ Roncero-Martin R Vera V Pedrera-Zamorano JD Cytotoxic effects of curcumin in osteosarcoma cells
description	JM Moran, FJ Rodriguez-Velasco, R Roncero-Martin, V Vera, JD Pedrera-Zamorano Metabolic Bone Diseases Research Group, University of Extremadura, Cáceres, SpainWe read with interest the results of the study from Chang et al1 in the International Journal of Nanomedicine. This article shows that curcumin (diferuloymethane), a phenolic compound extracted from the natural plant Curcuma longa L., exerts higher cytotoxicity in osteosarcoma MG-63 cells than in healthy human osteoblasts. Based on the dosages provided by the authors it is hypothesized that with the appropriate drug carriers, curcumin could be delivered to bone tumors and selectively kill osteosarcoma cells without harming healthy osteoblasts. This hypothesis is based in the data provided that claims the dose needed to exert a significant cytotoxicity on osteosarcoma cells was much lower than that needed to exert the same effect on healthy human osteoblasts. The topic of this study is of importance for both cancer and metabolic bone disease fields, we appreciate the methodology of the study, nevertheless we believe that the hypothesis formulated by the authors and their conclusion deserves further comment.View original paper by Chang and colleagues.
format	article
author	Moran JM Rodriguez-Velasco FJ Roncero-Martin R Vera V Pedrera-Zamorano JD
author_facet	Moran JM Rodriguez-Velasco FJ Roncero-Martin R Vera V Pedrera-Zamorano JD
author_sort	Moran JM
title	Cytotoxic effects of curcumin in osteosarcoma cells
title_short	Cytotoxic effects of curcumin in osteosarcoma cells
title_full	Cytotoxic effects of curcumin in osteosarcoma cells
title_fullStr	Cytotoxic effects of curcumin in osteosarcoma cells
title_full_unstemmed	Cytotoxic effects of curcumin in osteosarcoma cells
title_sort	cytotoxic effects of curcumin in osteosarcoma cells
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/b536de76961c43f1a6af50e1df4f055a
work_keys_str_mv	AT moranjm cytotoxiceffectsofcurcumininosteosarcomacells AT rodriguezvelascofj cytotoxiceffectsofcurcumininosteosarcomacells AT ronceromartinr cytotoxiceffectsofcurcumininosteosarcomacells AT verav cytotoxiceffectsofcurcumininosteosarcomacells AT pedrerazamoranojd cytotoxiceffectsofcurcumininosteosarcomacells
_version_	1718400788875706368

Cytotoxic effects of curcumin in osteosarcoma cells

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