Review of Curcumin Physicochemical Targeting Delivery System

Lanmei Li,1,2,* Xiaomei Zhang,3,* Chao Pi,1 Hongru Yang,4 Xiaoli Zheng,5 Ling Zhao,1 Yumeng Wei1 1Central Nervous System Drug Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, People’s Republic of China; 2Nanchong Key Laboratory o...

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Autores principales:	Li L, Zhang X, Pi C, Yang H, Zheng X, Zhao L, Wei Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	curcumin targeted delivery system ph-sensitive magnetic-response thermo-sensitive cancer Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b5371a35c21c47598478ffeca88a6605
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spelling	oai:doaj.org-article:b5371a35c21c47598478ffeca88a66052021-12-02T15:12:17ZReview of Curcumin Physicochemical Targeting Delivery System1178-2013https://doaj.org/article/b5371a35c21c47598478ffeca88a66052020-12-01T00:00:00Zhttps://www.dovepress.com/review-of-curcumin-physicochemical-targeting-delivery-system-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Lanmei Li,1,2,* Xiaomei Zhang,3,* Chao Pi,1 Hongru Yang,4 Xiaoli Zheng,5 Ling Zhao,1 Yumeng Wei1 1Central Nervous System Drug Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, People’s Republic of China; 2Nanchong Key Laboratory of Individualized Drug Therapy, Department of Pharmacy, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan 637000, People’s Republic of China; 3Institute of Medicinal Chemistry of Chinese Medicine, Chongqing Academy of Chinese MateriaMedica, Chongqing 400065, People’s Republic of China; 4Department of Oncology of Luzhou People’s Hospital, Luzhou, Sichuan 646000, People’s Republic of China; 5Basic Medical College of Southwest Medical University, Luzhou, Sichuan 646000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ling Zhao; Yumeng WeiSchool of Pharmacy, Southwest Medical University, No. 3-319, Zhongshan Road, Jiangyang District, Luzhou City, Sichuan Province 646000, People’s Republic of ChinaTel/Fax +86 830 3162292Email zhaoling-998@163.com; weiyumeng-268@163.comAbstract: Curcumin (CUR), as a traditional Chinese medicine monomer extracted from the rhizomes of some plants in Ginkgo and Araceae, has shown a wide range of therapeutic and pharmacological activities such as anti-tumor, anti-inflammatory, anti-oxidation, anti-virus, anti-liver fibrosis, anti-atherosclerosis, and anti-Alzheimer’s disease. However, some issues significantly affect its biological activity, such as low aqueous solubility, physico-chemical instability, poor bioavailability, and low targeting efficacy. In order to further improve its curative effect, numerous efficient drug delivery systems have been carried out. Among them, physicochemical targeting preparations could improve the properties, targeting ability, and biological activity of CUR. Therefore, in this review, CUR carrier systems are discussed that are driven by physicochemical characteristics of the microenvironment (eg, pH variation of tumorous tissues), affected by external influences like magnetic fields and vehicles formulated with thermo-sensitive materials.Keywords: curcumin, targeted delivery system, pH-sensitive, magnetic-response, thermo-sensitive, cancerLi LZhang XPi CYang HZheng XZhao LWei YDove Medical Pressarticlecurcumintargeted delivery systemph-sensitivemagnetic-responsethermo-sensitivecancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 9799-9821 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	curcumin targeted delivery system ph-sensitive magnetic-response thermo-sensitive cancer Medicine (General) R5-920
spellingShingle	curcumin targeted delivery system ph-sensitive magnetic-response thermo-sensitive cancer Medicine (General) R5-920 Li L Zhang X Pi C Yang H Zheng X Zhao L Wei Y Review of Curcumin Physicochemical Targeting Delivery System
description	Lanmei Li,1,2,* Xiaomei Zhang,3,* Chao Pi,1 Hongru Yang,4 Xiaoli Zheng,5 Ling Zhao,1 Yumeng Wei1 1Central Nervous System Drug Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, People’s Republic of China; 2Nanchong Key Laboratory of Individualized Drug Therapy, Department of Pharmacy, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan 637000, People’s Republic of China; 3Institute of Medicinal Chemistry of Chinese Medicine, Chongqing Academy of Chinese MateriaMedica, Chongqing 400065, People’s Republic of China; 4Department of Oncology of Luzhou People’s Hospital, Luzhou, Sichuan 646000, People’s Republic of China; 5Basic Medical College of Southwest Medical University, Luzhou, Sichuan 646000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ling Zhao; Yumeng WeiSchool of Pharmacy, Southwest Medical University, No. 3-319, Zhongshan Road, Jiangyang District, Luzhou City, Sichuan Province 646000, People’s Republic of ChinaTel/Fax +86 830 3162292Email zhaoling-998@163.com; weiyumeng-268@163.comAbstract: Curcumin (CUR), as a traditional Chinese medicine monomer extracted from the rhizomes of some plants in Ginkgo and Araceae, has shown a wide range of therapeutic and pharmacological activities such as anti-tumor, anti-inflammatory, anti-oxidation, anti-virus, anti-liver fibrosis, anti-atherosclerosis, and anti-Alzheimer’s disease. However, some issues significantly affect its biological activity, such as low aqueous solubility, physico-chemical instability, poor bioavailability, and low targeting efficacy. In order to further improve its curative effect, numerous efficient drug delivery systems have been carried out. Among them, physicochemical targeting preparations could improve the properties, targeting ability, and biological activity of CUR. Therefore, in this review, CUR carrier systems are discussed that are driven by physicochemical characteristics of the microenvironment (eg, pH variation of tumorous tissues), affected by external influences like magnetic fields and vehicles formulated with thermo-sensitive materials.Keywords: curcumin, targeted delivery system, pH-sensitive, magnetic-response, thermo-sensitive, cancer
format	article
author	Li L Zhang X Pi C Yang H Zheng X Zhao L Wei Y
author_facet	Li L Zhang X Pi C Yang H Zheng X Zhao L Wei Y
author_sort	Li L
title	Review of Curcumin Physicochemical Targeting Delivery System
title_short	Review of Curcumin Physicochemical Targeting Delivery System
title_full	Review of Curcumin Physicochemical Targeting Delivery System
title_fullStr	Review of Curcumin Physicochemical Targeting Delivery System
title_full_unstemmed	Review of Curcumin Physicochemical Targeting Delivery System
title_sort	review of curcumin physicochemical targeting delivery system
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/b5371a35c21c47598478ffeca88a6605
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Review of Curcumin Physicochemical Targeting Delivery System

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