Lack of association of the M129V polymorphism of the PRNP gene with pseudoexfoliation syndrome

Marios P Giannakopoulos,1 Anna G Antonacopoulou,2 Anastasia E Kottorou,2 Haralabos P Kalofonos,2 Sotirios P Gartaganis1 1Department of Ophthalmology, School of Medicine, 2Department of Medicine, Molecular Oncology Laboratory, Division of Oncology, University of Patras, Rion, Greece Purpose: In thi...

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Autores principales:	Giannakopoulos MP, Antonacopoulou AG, Kottorou AE, Kalofonos HP, Gartaganis SP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Psedoexfoliation syndrome PEX M129V polymorphism Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/b53be05230f74fa0b84f761cd660c3ec
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spelling	oai:doaj.org-article:b53be05230f74fa0b84f761cd660c3ec2021-12-02T02:31:09ZLack of association of the M129V polymorphism of the PRNP gene with pseudoexfoliation syndrome1177-5483https://doaj.org/article/b53be05230f74fa0b84f761cd660c3ec2016-04-01T00:00:00Zhttps://www.dovepress.com/lack-of-association-of-the-m129v-polymorphism-of-the-prnp-gene-with-ps-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Marios P Giannakopoulos,1 Anna G Antonacopoulou,2 Anastasia E Kottorou,2 Haralabos P Kalofonos,2 Sotirios P Gartaganis1 1Department of Ophthalmology, School of Medicine, 2Department of Medicine, Molecular Oncology Laboratory, Division of Oncology, University of Patras, Rion, Greece Purpose: In this study we aimed to evaluate the polymorphism at codon 129 (M129V) of the PRNP gene as a secondary risk factor for pseudoexfoliation syndrome (PEX). Methods: Two hundred and seventy-five unrelated subjects, including 156 patients with PEX and 119 unrelated control subjects, were recruited from the University Hospital of Patras, Greece. All patients and controls were of Caucasian or European ancestry. The PRNP M129V (A/G) single-nucleotide polymorphism was genotyped by real-time polymerase chain reactions. Association of the polymorphism with PEX was assessed using the two-sided Pearson’s chi-squared or Fisher’s exact test.Result: No significant difference between patients and controls was observed in terms of frequencies of alleles and genotypes of the PRNP gene.Conclusion: Polymorphism at M129V of the PRNP gene was evaluated as a secondary risk factor for developing PEX. Our results suggest that this PRNP gene polymorphism is not associated with PEX. Keywords: pseudoexfoliation syndrome, polymorphism, M129V, PEX, protein folding disordersGiannakopoulos MPAntonacopoulou AGKottorou AEKalofonos HPGartaganis SPDove Medical PressarticlePsedoexfoliation syndromePEXM129VpolymorphismOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 731-734 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psedoexfoliation syndrome PEX M129V polymorphism Ophthalmology RE1-994
spellingShingle	Psedoexfoliation syndrome PEX M129V polymorphism Ophthalmology RE1-994 Giannakopoulos MP Antonacopoulou AG Kottorou AE Kalofonos HP Gartaganis SP Lack of association of the M129V polymorphism of the PRNP gene with pseudoexfoliation syndrome
description	Marios P Giannakopoulos,1 Anna G Antonacopoulou,2 Anastasia E Kottorou,2 Haralabos P Kalofonos,2 Sotirios P Gartaganis1 1Department of Ophthalmology, School of Medicine, 2Department of Medicine, Molecular Oncology Laboratory, Division of Oncology, University of Patras, Rion, Greece Purpose: In this study we aimed to evaluate the polymorphism at codon 129 (M129V) of the PRNP gene as a secondary risk factor for pseudoexfoliation syndrome (PEX). Methods: Two hundred and seventy-five unrelated subjects, including 156 patients with PEX and 119 unrelated control subjects, were recruited from the University Hospital of Patras, Greece. All patients and controls were of Caucasian or European ancestry. The PRNP M129V (A/G) single-nucleotide polymorphism was genotyped by real-time polymerase chain reactions. Association of the polymorphism with PEX was assessed using the two-sided Pearson’s chi-squared or Fisher’s exact test.Result: No significant difference between patients and controls was observed in terms of frequencies of alleles and genotypes of the PRNP gene.Conclusion: Polymorphism at M129V of the PRNP gene was evaluated as a secondary risk factor for developing PEX. Our results suggest that this PRNP gene polymorphism is not associated with PEX. Keywords: pseudoexfoliation syndrome, polymorphism, M129V, PEX, protein folding disorders
format	article
author	Giannakopoulos MP Antonacopoulou AG Kottorou AE Kalofonos HP Gartaganis SP
author_facet	Giannakopoulos MP Antonacopoulou AG Kottorou AE Kalofonos HP Gartaganis SP
author_sort	Giannakopoulos MP
title	Lack of association of the M129V polymorphism of the PRNP gene with pseudoexfoliation syndrome
title_short	Lack of association of the M129V polymorphism of the PRNP gene with pseudoexfoliation syndrome
title_full	Lack of association of the M129V polymorphism of the PRNP gene with pseudoexfoliation syndrome
title_fullStr	Lack of association of the M129V polymorphism of the PRNP gene with pseudoexfoliation syndrome
title_full_unstemmed	Lack of association of the M129V polymorphism of the PRNP gene with pseudoexfoliation syndrome
title_sort	lack of association of the m129v polymorphism of the prnp gene with pseudoexfoliation syndrome
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/b53be05230f74fa0b84f761cd660c3ec
work_keys_str_mv	AT giannakopoulosmp lackofassociationofthem129vpolymorphismoftheprnpgenewithpseudoexfoliationsyndrome AT antonacopoulouag lackofassociationofthem129vpolymorphismoftheprnpgenewithpseudoexfoliationsyndrome AT kottorouae lackofassociationofthem129vpolymorphismoftheprnpgenewithpseudoexfoliationsyndrome AT kalofonoshp lackofassociationofthem129vpolymorphismoftheprnpgenewithpseudoexfoliationsyndrome AT gartaganissp lackofassociationofthem129vpolymorphismoftheprnpgenewithpseudoexfoliationsyndrome
_version_	1718402434133393408

Lack of association of the M129V polymorphism of the PRNP gene with pseudoexfoliation syndrome

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