Adherence to the Mediterranean diet assessed by a novel dietary biomarker score and mortality in older adults: the InCHIANTI cohort study

Abstract Background Dietary biomarkers may complement dietary intake assessment made by dietary questionnaires. We developed an a-posteriori dietary biomarkers score based on Mediterranean diet food groups and evaluated its association with mortality. Methods 642 participants (56% female), aged ≥65...

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Auteurs principaux:	Nicole Hidalgo-Liberona, Tomás Meroño, Raul Zamora-Ros, Montserrat Rabassa, Richard Semba, Toshiko Tanaka, Stefania Bandinelli, Luigi Ferrucci, Cristina Andres-Lacueva, Antonio Cherubini
Format:	article
Langue:	EN
Publié:	BMC 2021
Sujets:	Dietary biomarkers Older adults Mediterranean diet Mortality Polyphenols Carotenoids Medicine R
Accès en ligne:	https://doaj.org/article/b53e921a0f7b45459884778c0b5f8cee
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spelling	oai:doaj.org-article:b53e921a0f7b45459884778c0b5f8cee2021-11-28T12:15:23ZAdherence to the Mediterranean diet assessed by a novel dietary biomarker score and mortality in older adults: the InCHIANTI cohort study10.1186/s12916-021-02154-71741-7015https://doaj.org/article/b53e921a0f7b45459884778c0b5f8cee2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12916-021-02154-7https://doaj.org/toc/1741-7015Abstract Background Dietary biomarkers may complement dietary intake assessment made by dietary questionnaires. We developed an a-posteriori dietary biomarkers score based on Mediterranean diet food groups and evaluated its association with mortality. Methods 642 participants (56% female), aged ≥65 years, with complete data on dietary biomarkers were followed during 20 years in the InCHIANTI cohort study (Tuscany, Italy). The main outcomes were all-cause, cardiovascular, and cancer mortality. Dietary biomarkers were selected from literature and from correlation analyses with dietary intakes of Mediterranean diet food groups in the study. The baseline levels of the following dietary biomarkers were chosen: urinary total polyphenols and resveratrol metabolites, and plasma carotenoids, selenium, vitamin B12, linolenic, eicosapentaenoic and docosahexaenoic acids, and the mono-unsaturated/saturated fatty acid ratio. Associations of the Mediterranean diet score using dietary biomarkers and a validated food frequency questionnaire (FFQ) (as tertiles) with mortality were assessed through Cox regression. Results During the 20-year follow-up [median (Q1–Q3), 14 (8–18) years], and 435 deaths occurred (139 from cardiovascular diseases and 89 from cancer-related causes). In the fully adjusted models, the dietary biomarker-Mediterranean diet score was inversely associated with all-cause (HRT3vs.T1 0.72; 95%CI 0.56–0.91) and cardiovascular (HRT3vs.T1 0.60; 95%CI 0.38–0.93), but not with cancer mortality. Associations between the FFQ-Mediterranean diet score and mortality were not statistically significant. Conclusions A greater adherence at baseline to a Mediterranean diet assessed by a dietary biomarker score was associated with a lower risk of mortality in older adults during a 20-year follow-up. The measurement of dietary biomarkers may contribute to guide individualized dietary counseling to older people. Trial registration NCT01331512Nicole Hidalgo-LiberonaTomás MeroñoRaul Zamora-RosMontserrat RabassaRichard SembaToshiko TanakaStefania BandinelliLuigi FerrucciCristina Andres-LacuevaAntonio CherubiniBMCarticleDietary biomarkersOlder adultsMediterranean dietMortalityPolyphenolsCarotenoidsMedicineRENBMC Medicine, Vol 19, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dietary biomarkers Older adults Mediterranean diet Mortality Polyphenols Carotenoids Medicine R
spellingShingle	Dietary biomarkers Older adults Mediterranean diet Mortality Polyphenols Carotenoids Medicine R Nicole Hidalgo-Liberona Tomás Meroño Raul Zamora-Ros Montserrat Rabassa Richard Semba Toshiko Tanaka Stefania Bandinelli Luigi Ferrucci Cristina Andres-Lacueva Antonio Cherubini Adherence to the Mediterranean diet assessed by a novel dietary biomarker score and mortality in older adults: the InCHIANTI cohort study
description	Abstract Background Dietary biomarkers may complement dietary intake assessment made by dietary questionnaires. We developed an a-posteriori dietary biomarkers score based on Mediterranean diet food groups and evaluated its association with mortality. Methods 642 participants (56% female), aged ≥65 years, with complete data on dietary biomarkers were followed during 20 years in the InCHIANTI cohort study (Tuscany, Italy). The main outcomes were all-cause, cardiovascular, and cancer mortality. Dietary biomarkers were selected from literature and from correlation analyses with dietary intakes of Mediterranean diet food groups in the study. The baseline levels of the following dietary biomarkers were chosen: urinary total polyphenols and resveratrol metabolites, and plasma carotenoids, selenium, vitamin B12, linolenic, eicosapentaenoic and docosahexaenoic acids, and the mono-unsaturated/saturated fatty acid ratio. Associations of the Mediterranean diet score using dietary biomarkers and a validated food frequency questionnaire (FFQ) (as tertiles) with mortality were assessed through Cox regression. Results During the 20-year follow-up [median (Q1–Q3), 14 (8–18) years], and 435 deaths occurred (139 from cardiovascular diseases and 89 from cancer-related causes). In the fully adjusted models, the dietary biomarker-Mediterranean diet score was inversely associated with all-cause (HRT3vs.T1 0.72; 95%CI 0.56–0.91) and cardiovascular (HRT3vs.T1 0.60; 95%CI 0.38–0.93), but not with cancer mortality. Associations between the FFQ-Mediterranean diet score and mortality were not statistically significant. Conclusions A greater adherence at baseline to a Mediterranean diet assessed by a dietary biomarker score was associated with a lower risk of mortality in older adults during a 20-year follow-up. The measurement of dietary biomarkers may contribute to guide individualized dietary counseling to older people. Trial registration NCT01331512
format	article
author	Nicole Hidalgo-Liberona Tomás Meroño Raul Zamora-Ros Montserrat Rabassa Richard Semba Toshiko Tanaka Stefania Bandinelli Luigi Ferrucci Cristina Andres-Lacueva Antonio Cherubini
author_facet	Nicole Hidalgo-Liberona Tomás Meroño Raul Zamora-Ros Montserrat Rabassa Richard Semba Toshiko Tanaka Stefania Bandinelli Luigi Ferrucci Cristina Andres-Lacueva Antonio Cherubini
author_sort	Nicole Hidalgo-Liberona
title	Adherence to the Mediterranean diet assessed by a novel dietary biomarker score and mortality in older adults: the InCHIANTI cohort study
title_short	Adherence to the Mediterranean diet assessed by a novel dietary biomarker score and mortality in older adults: the InCHIANTI cohort study
title_full	Adherence to the Mediterranean diet assessed by a novel dietary biomarker score and mortality in older adults: the InCHIANTI cohort study
title_fullStr	Adherence to the Mediterranean diet assessed by a novel dietary biomarker score and mortality in older adults: the InCHIANTI cohort study
title_full_unstemmed	Adherence to the Mediterranean diet assessed by a novel dietary biomarker score and mortality in older adults: the InCHIANTI cohort study
title_sort	adherence to the mediterranean diet assessed by a novel dietary biomarker score and mortality in older adults: the inchianti cohort study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/b53e921a0f7b45459884778c0b5f8cee
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Adherence to the Mediterranean diet assessed by a novel dietary biomarker score and mortality in older adults: the InCHIANTI cohort study

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