Hemoglobin and adult height loss among Japanese workers: A retrospective study.

Height loss starting in middle age is reported to be associated with increased all-cause and cardiovascular mortality later in life. However, the mechanisms underlying this association are unclear. Hypoxia and oxidative stress, which are known causes of cardiovascular disease, could be reduced by he...

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Autores principales:	Yuji Shimizu, Hidenobu Hayakawa, Midori Takada, Takeo Okada, Masahiko Kiyama
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b53f77209113491fb015c4e9477f1187
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spelling	oai:doaj.org-article:b53f77209113491fb015c4e9477f11872021-12-02T20:17:54ZHemoglobin and adult height loss among Japanese workers: A retrospective study.1932-620310.1371/journal.pone.0256281https://doaj.org/article/b53f77209113491fb015c4e9477f11872021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256281https://doaj.org/toc/1932-6203Height loss starting in middle age is reported to be associated with increased all-cause and cardiovascular mortality later in life. However, the mechanisms underlying this association are unclear. Hypoxia and oxidative stress, which are known causes of cardiovascular disease, could be reduced by hemoglobin. Therefore, hemoglobin could be inversely associated with height loss. However, high body mass index (BMI) is a known risk factor for intervertebral disc disorder, a known cause of height loss in adults. High BMI might confound the association between hemoglobin and height loss. Therefore, we performed analyses stratified by BMI status. To clarify the association between hemoglobin and height loss, we conducted a retrospective study of Japanese workers (6,471 men and 3,180 women) aged 40-74 years. Height loss was defined as being in the highest quintile of height decrease per year. In men overall and men with BMI <25 kg/m2, hemoglobin was significantly inversely associated with height loss; but no association was observed for men with high BMI (BMI ≥25 kg/m2) and for women. For men, after adjusting for known cardiovascular risk factors, adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for height loss with each 1 standard deviation (SD) increase in hemoglobin (1.0 g/dL for men and 0.8g/dL for women) were 0.89 (0.83, 0.95) for men overall, 0.82 (0.75, 0.89) for men who do not have high BMI, and 1.01 (0.92, 1.12) for men with high BMI. For women, the corresponding values were 0.97 (0.89, 1.06), 0.98 (0.89, 1.09), and 0.93 (0.75, 1.15) respectively. Hemoglobin is significantly inversely associated with height loss in men who do not have high BMI, but not in men with high BMI or women. These results help clarify the mechanisms underlying height loss, which has been reported to be associated with a higher risk of mortality in adults.Yuji ShimizuHidenobu HayakawaMidori TakadaTakeo OkadaMasahiko KiyamaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256281 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuji Shimizu Hidenobu Hayakawa Midori Takada Takeo Okada Masahiko Kiyama Hemoglobin and adult height loss among Japanese workers: A retrospective study.
description	Height loss starting in middle age is reported to be associated with increased all-cause and cardiovascular mortality later in life. However, the mechanisms underlying this association are unclear. Hypoxia and oxidative stress, which are known causes of cardiovascular disease, could be reduced by hemoglobin. Therefore, hemoglobin could be inversely associated with height loss. However, high body mass index (BMI) is a known risk factor for intervertebral disc disorder, a known cause of height loss in adults. High BMI might confound the association between hemoglobin and height loss. Therefore, we performed analyses stratified by BMI status. To clarify the association between hemoglobin and height loss, we conducted a retrospective study of Japanese workers (6,471 men and 3,180 women) aged 40-74 years. Height loss was defined as being in the highest quintile of height decrease per year. In men overall and men with BMI <25 kg/m2, hemoglobin was significantly inversely associated with height loss; but no association was observed for men with high BMI (BMI ≥25 kg/m2) and for women. For men, after adjusting for known cardiovascular risk factors, adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for height loss with each 1 standard deviation (SD) increase in hemoglobin (1.0 g/dL for men and 0.8g/dL for women) were 0.89 (0.83, 0.95) for men overall, 0.82 (0.75, 0.89) for men who do not have high BMI, and 1.01 (0.92, 1.12) for men with high BMI. For women, the corresponding values were 0.97 (0.89, 1.06), 0.98 (0.89, 1.09), and 0.93 (0.75, 1.15) respectively. Hemoglobin is significantly inversely associated with height loss in men who do not have high BMI, but not in men with high BMI or women. These results help clarify the mechanisms underlying height loss, which has been reported to be associated with a higher risk of mortality in adults.
format	article
author	Yuji Shimizu Hidenobu Hayakawa Midori Takada Takeo Okada Masahiko Kiyama
author_facet	Yuji Shimizu Hidenobu Hayakawa Midori Takada Takeo Okada Masahiko Kiyama
author_sort	Yuji Shimizu
title	Hemoglobin and adult height loss among Japanese workers: A retrospective study.
title_short	Hemoglobin and adult height loss among Japanese workers: A retrospective study.
title_full	Hemoglobin and adult height loss among Japanese workers: A retrospective study.
title_fullStr	Hemoglobin and adult height loss among Japanese workers: A retrospective study.
title_full_unstemmed	Hemoglobin and adult height loss among Japanese workers: A retrospective study.
title_sort	hemoglobin and adult height loss among japanese workers: a retrospective study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/b53f77209113491fb015c4e9477f1187
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Hemoglobin and adult height loss among Japanese workers: A retrospective study.

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