Association between skeletal muscle mass and mammographic breast density

Abstract Mammographic density (MD) of the breast and body mass index (BMI) are inversely associated with each other, but have inconsistent associations with respect to the risk of breast cancer. Skeletal muscle mass index (SMI) has been considered to reflect a relatively accurate fat and muscle perc...

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Autores principales:	Kwan Ho Lee, Seoung Wan Chae, Ji Sup Yun, Yong Lai Park, Chan Heun Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b540b511912a4db386a7e7262d89c567
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spelling	oai:doaj.org-article:b540b511912a4db386a7e7262d89c5672021-12-02T18:51:46ZAssociation between skeletal muscle mass and mammographic breast density10.1038/s41598-021-96390-92045-2322https://doaj.org/article/b540b511912a4db386a7e7262d89c5672021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96390-9https://doaj.org/toc/2045-2322Abstract Mammographic density (MD) of the breast and body mass index (BMI) are inversely associated with each other, but have inconsistent associations with respect to the risk of breast cancer. Skeletal muscle mass index (SMI) has been considered to reflect a relatively accurate fat and muscle percentage in the body. So, we evaluated the relation between SMI and MD. A cross-sectional study was performed in 143,456 women who underwent comprehensive examinations from 2012 to 2016. BMI was adjusted to analyze whether SMI is an independent factor predicting dense breast. After adjustment for confounding factors including BMI, the odds ratios for MD for the dense breasts was between the highest and lowest quartiles of SMI at 2.65 for premenopausal women and at 2.39 for postmenopausal women. SMI was a significant predictor for MD, which could be due to the similar growth mechanism of the skeletal muscle and breast parenchymal tissue. Further studies are needed to understand the causal link between muscularity, MD and breast cancer risk.Kwan Ho LeeSeoung Wan ChaeJi Sup YunYong Lai ParkChan Heun ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kwan Ho Lee Seoung Wan Chae Ji Sup Yun Yong Lai Park Chan Heun Park Association between skeletal muscle mass and mammographic breast density
description	Abstract Mammographic density (MD) of the breast and body mass index (BMI) are inversely associated with each other, but have inconsistent associations with respect to the risk of breast cancer. Skeletal muscle mass index (SMI) has been considered to reflect a relatively accurate fat and muscle percentage in the body. So, we evaluated the relation between SMI and MD. A cross-sectional study was performed in 143,456 women who underwent comprehensive examinations from 2012 to 2016. BMI was adjusted to analyze whether SMI is an independent factor predicting dense breast. After adjustment for confounding factors including BMI, the odds ratios for MD for the dense breasts was between the highest and lowest quartiles of SMI at 2.65 for premenopausal women and at 2.39 for postmenopausal women. SMI was a significant predictor for MD, which could be due to the similar growth mechanism of the skeletal muscle and breast parenchymal tissue. Further studies are needed to understand the causal link between muscularity, MD and breast cancer risk.
format	article
author	Kwan Ho Lee Seoung Wan Chae Ji Sup Yun Yong Lai Park Chan Heun Park
author_facet	Kwan Ho Lee Seoung Wan Chae Ji Sup Yun Yong Lai Park Chan Heun Park
author_sort	Kwan Ho Lee
title	Association between skeletal muscle mass and mammographic breast density
title_short	Association between skeletal muscle mass and mammographic breast density
title_full	Association between skeletal muscle mass and mammographic breast density
title_fullStr	Association between skeletal muscle mass and mammographic breast density
title_full_unstemmed	Association between skeletal muscle mass and mammographic breast density
title_sort	association between skeletal muscle mass and mammographic breast density
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b540b511912a4db386a7e7262d89c567
work_keys_str_mv	AT kwanholee associationbetweenskeletalmusclemassandmammographicbreastdensity AT seoungwanchae associationbetweenskeletalmusclemassandmammographicbreastdensity AT jisupyun associationbetweenskeletalmusclemassandmammographicbreastdensity AT yonglaipark associationbetweenskeletalmusclemassandmammographicbreastdensity AT chanheunpark associationbetweenskeletalmusclemassandmammographicbreastdensity
_version_	1718377406828380160

Association between skeletal muscle mass and mammographic breast density

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