Small molecules against B-RAF (BRAF) Val600Glu (V600E) single mutation

Florin Zaharie,1,* Roxana Cojocneanu-Petric,1,* Mihai Muresan,1 Ioana Frinc,2 Delia Dima,2 Bobe Petrushev,3 Alina Tanase,4 Cristian Berce,1 Mariana Chitic,2 Ioana Berindan-Neagoe,1 Valentina Pileczki,1 Alexandru Irimie,5 Ciprian Tomuleasa2 1Iuliu Hatieganu University of Medicine and Pharmacy, 2Depar...

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Autores principales:	Zaharie F, Cojocneanu-Petric R, Muresan M, Frinc I, Dima D, Petrushev B, Tanase A, Berce C, Chitic M, Berindan-Neagoe I, Pileczki V, Irimie A, Tomuleasa C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b540d2abbc8047b29da8f1d0cee14b02
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spelling	oai:doaj.org-article:b540d2abbc8047b29da8f1d0cee14b022021-12-02T05:02:13ZSmall molecules against B-RAF (BRAF) Val600Glu (V600E) single mutation1178-2013https://doaj.org/article/b540d2abbc8047b29da8f1d0cee14b022015-07-01T00:00:00Zhttp://www.dovepress.com/small-molecules-against-b-raf-braf-val600glu-v600e-single-mutation-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Florin Zaharie,1,* Roxana Cojocneanu-Petric,1,* Mihai Muresan,1 Ioana Frinc,2 Delia Dima,2 Bobe Petrushev,3 Alina Tanase,4 Cristian Berce,1 Mariana Chitic,2 Ioana Berindan-Neagoe,1 Valentina Pileczki,1 Alexandru Irimie,5 Ciprian Tomuleasa2 1Iuliu Hatieganu University of Medicine and Pharmacy, 2Department of Hematology, Ion Chiricuta Oncology Institute, 3Department of Pathology, Emergency University Hospital, Cluj Napoca, 4Department of Stem Cell Transplantation, Fundeni Clinical Institute, Bucharest, 5Department of Surgery, Ion Chiricuta Oncology Institute, Cluj Napoca, Romania *These authors contributed equally to this communicationWe have read with great interest the paper by Tang and Chen1 published in the most recent issue of the International Journal of Nanomedicine, in which the authors describe the protocol by which scientists constructed the ideal BRAF (V600E)-modeled structure through homology modeling and introduced the method of structure-based docking or virtual screening from a large compound database. They concluded that BRAF (V600E) has a quite prominent structural or conformational variation when compared to the wild-type BRAF protein by matrix of root mean square fluctuation and principal component analysis. On the basis of structure-based virtual screening, ligand-based quantitative structure activity relationship models, and molecular dynamics simulation, we recommend aknadicine and 16beta-hydroxy-19s-vindolinine N-oxide as potent compounds for developing novel inhibitors in the future. Read the original article Zaharie FCojocneanu-Petric RMuresan MFrinc IDima DPetrushev BTanase ABerce CChitic MBerindan-Neagoe IPileczki VIrimie ATomuleasa CDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 4897-4899 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zaharie F Cojocneanu-Petric R Muresan M Frinc I Dima D Petrushev B Tanase A Berce C Chitic M Berindan-Neagoe I Pileczki V Irimie A Tomuleasa C Small molecules against B-RAF (BRAF) Val600Glu (V600E) single mutation
description	Florin Zaharie,1,* Roxana Cojocneanu-Petric,1,* Mihai Muresan,1 Ioana Frinc,2 Delia Dima,2 Bobe Petrushev,3 Alina Tanase,4 Cristian Berce,1 Mariana Chitic,2 Ioana Berindan-Neagoe,1 Valentina Pileczki,1 Alexandru Irimie,5 Ciprian Tomuleasa2 1Iuliu Hatieganu University of Medicine and Pharmacy, 2Department of Hematology, Ion Chiricuta Oncology Institute, 3Department of Pathology, Emergency University Hospital, Cluj Napoca, 4Department of Stem Cell Transplantation, Fundeni Clinical Institute, Bucharest, 5Department of Surgery, Ion Chiricuta Oncology Institute, Cluj Napoca, Romania *These authors contributed equally to this communicationWe have read with great interest the paper by Tang and Chen1 published in the most recent issue of the International Journal of Nanomedicine, in which the authors describe the protocol by which scientists constructed the ideal BRAF (V600E)-modeled structure through homology modeling and introduced the method of structure-based docking or virtual screening from a large compound database. They concluded that BRAF (V600E) has a quite prominent structural or conformational variation when compared to the wild-type BRAF protein by matrix of root mean square fluctuation and principal component analysis. On the basis of structure-based virtual screening, ligand-based quantitative structure activity relationship models, and molecular dynamics simulation, we recommend aknadicine and 16beta-hydroxy-19s-vindolinine N-oxide as potent compounds for developing novel inhibitors in the future. Read the original article
format	article
author	Zaharie F Cojocneanu-Petric R Muresan M Frinc I Dima D Petrushev B Tanase A Berce C Chitic M Berindan-Neagoe I Pileczki V Irimie A Tomuleasa C
author_facet	Zaharie F Cojocneanu-Petric R Muresan M Frinc I Dima D Petrushev B Tanase A Berce C Chitic M Berindan-Neagoe I Pileczki V Irimie A Tomuleasa C
author_sort	Zaharie F
title	Small molecules against B-RAF (BRAF) Val600Glu (V600E) single mutation
title_short	Small molecules against B-RAF (BRAF) Val600Glu (V600E) single mutation
title_full	Small molecules against B-RAF (BRAF) Val600Glu (V600E) single mutation
title_fullStr	Small molecules against B-RAF (BRAF) Val600Glu (V600E) single mutation
title_full_unstemmed	Small molecules against B-RAF (BRAF) Val600Glu (V600E) single mutation
title_sort	small molecules against b-raf (braf) val600glu (v600e) single mutation
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/b540d2abbc8047b29da8f1d0cee14b02
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Small molecules against B-RAF (BRAF) Val600Glu (V600E) single mutation

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