A tissue-mimetic nano-fibrillar hybrid injectable hydrogel for potential soft tissue engineering applications

Abstract While collagen type I (Col-I) is commonly used as a structural component of biomaterials, collagen type III (Col-III), another fibril forming collagen ubiquitous in many soft tissues, has not previously been used. In the present study, the novel concept of an injectable hydrogel with semi-i...

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Autores principales:	Neda Latifi, Meisam Asgari, Hojatollah Vali, Luc Mongeau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b54bf2ae7c6649c1a34dc9ccf621db33
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spelling	oai:doaj.org-article:b54bf2ae7c6649c1a34dc9ccf621db332021-12-02T15:08:15ZA tissue-mimetic nano-fibrillar hybrid injectable hydrogel for potential soft tissue engineering applications10.1038/s41598-017-18523-32045-2322https://doaj.org/article/b54bf2ae7c6649c1a34dc9ccf621db332018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-18523-3https://doaj.org/toc/2045-2322Abstract While collagen type I (Col-I) is commonly used as a structural component of biomaterials, collagen type III (Col-III), another fibril forming collagen ubiquitous in many soft tissues, has not previously been used. In the present study, the novel concept of an injectable hydrogel with semi-interpenetrating polymeric networks of heterotypic collagen fibrils, with tissue-specific Col-III to Col-I ratios, in a glycol-chitosan matrix was investigated. Col-III was introduced as a component of the novel hydrogel, inspired by its co-presence with Col-I in many soft tissues, its influence on the Col-I fibrillogenesis in terms of diameter and mechanics, and its established role in regulating scar formation. The hydrogel has a nano-fibrillar porous structure, and is mechanically stable under continuous dynamic stimulation. It was found to provide a longer half-life of about 35 days than similar hyaluronic acid-based hydrogels, and to support cell implantation in terms of viability, metabolic activity, adhesion and migration. The specific case of pure Col-III fibrils in a glycol-chitosan matrix was investigated. The proposed hydrogels meet many essential requirements for soft tissue engineering applications, particularly for mechanically challenged tissues such as vocal folds and heart valves.Neda LatifiMeisam AsgariHojatollah ValiLuc MongeauNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Neda Latifi Meisam Asgari Hojatollah Vali Luc Mongeau A tissue-mimetic nano-fibrillar hybrid injectable hydrogel for potential soft tissue engineering applications
description	Abstract While collagen type I (Col-I) is commonly used as a structural component of biomaterials, collagen type III (Col-III), another fibril forming collagen ubiquitous in many soft tissues, has not previously been used. In the present study, the novel concept of an injectable hydrogel with semi-interpenetrating polymeric networks of heterotypic collagen fibrils, with tissue-specific Col-III to Col-I ratios, in a glycol-chitosan matrix was investigated. Col-III was introduced as a component of the novel hydrogel, inspired by its co-presence with Col-I in many soft tissues, its influence on the Col-I fibrillogenesis in terms of diameter and mechanics, and its established role in regulating scar formation. The hydrogel has a nano-fibrillar porous structure, and is mechanically stable under continuous dynamic stimulation. It was found to provide a longer half-life of about 35 days than similar hyaluronic acid-based hydrogels, and to support cell implantation in terms of viability, metabolic activity, adhesion and migration. The specific case of pure Col-III fibrils in a glycol-chitosan matrix was investigated. The proposed hydrogels meet many essential requirements for soft tissue engineering applications, particularly for mechanically challenged tissues such as vocal folds and heart valves.
format	article
author	Neda Latifi Meisam Asgari Hojatollah Vali Luc Mongeau
author_facet	Neda Latifi Meisam Asgari Hojatollah Vali Luc Mongeau
author_sort	Neda Latifi
title	A tissue-mimetic nano-fibrillar hybrid injectable hydrogel for potential soft tissue engineering applications
title_short	A tissue-mimetic nano-fibrillar hybrid injectable hydrogel for potential soft tissue engineering applications
title_full	A tissue-mimetic nano-fibrillar hybrid injectable hydrogel for potential soft tissue engineering applications
title_fullStr	A tissue-mimetic nano-fibrillar hybrid injectable hydrogel for potential soft tissue engineering applications
title_full_unstemmed	A tissue-mimetic nano-fibrillar hybrid injectable hydrogel for potential soft tissue engineering applications
title_sort	tissue-mimetic nano-fibrillar hybrid injectable hydrogel for potential soft tissue engineering applications
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b54bf2ae7c6649c1a34dc9ccf621db33
work_keys_str_mv	AT nedalatifi atissuemimeticnanofibrillarhybridinjectablehydrogelforpotentialsofttissueengineeringapplications AT meisamasgari atissuemimeticnanofibrillarhybridinjectablehydrogelforpotentialsofttissueengineeringapplications AT hojatollahvali atissuemimeticnanofibrillarhybridinjectablehydrogelforpotentialsofttissueengineeringapplications AT lucmongeau atissuemimeticnanofibrillarhybridinjectablehydrogelforpotentialsofttissueengineeringapplications AT nedalatifi tissuemimeticnanofibrillarhybridinjectablehydrogelforpotentialsofttissueengineeringapplications AT meisamasgari tissuemimeticnanofibrillarhybridinjectablehydrogelforpotentialsofttissueengineeringapplications AT hojatollahvali tissuemimeticnanofibrillarhybridinjectablehydrogelforpotentialsofttissueengineeringapplications AT lucmongeau tissuemimeticnanofibrillarhybridinjectablehydrogelforpotentialsofttissueengineeringapplications
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A tissue-mimetic nano-fibrillar hybrid injectable hydrogel for potential soft tissue engineering applications

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