Associations of serum cystatin C with depressive symptoms and suicidal ideation in major depressive disorder

Abstract Background Individuals with major depressive disorder (MDD) have high suicidal ideation. There is evidence that serum cystatin C (Cys C) may be involved in the pathophysiology of MDD. The present study aimed to investigate Cys C concentration in patients with MDD and clarify its possible as...

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Auteurs principaux:	Ting Sun, Qian Chen, Yan Li
Format:	article
Langue:	EN
Publié:	BMC 2021
Sujets:	Depression Serum Cystatin C Depressive symptoms Suicidal ideation Psychiatry RC435-571
Accès en ligne:	https://doaj.org/article/b54bfac2d25246b8bbd044dac23d5944
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spelling	oai:doaj.org-article:b54bfac2d25246b8bbd044dac23d59442021-11-21T12:05:15ZAssociations of serum cystatin C with depressive symptoms and suicidal ideation in major depressive disorder10.1186/s12888-021-03509-31471-244Xhttps://doaj.org/article/b54bfac2d25246b8bbd044dac23d59442021-11-01T00:00:00Zhttps://doi.org/10.1186/s12888-021-03509-3https://doaj.org/toc/1471-244XAbstract Background Individuals with major depressive disorder (MDD) have high suicidal ideation. There is evidence that serum cystatin C (Cys C) may be involved in the pathophysiology of MDD. The present study aimed to investigate Cys C concentration in patients with MDD and clarify its possible association with depressive symptoms and suicidal ideation. Methods An online cross-sectional survey of 159 patients diagnosed with MDD was conducted. Serum Cys C levels were measured using ADVIA 2400 biochemical analyzer. The 24-item Hamilton Depression Scale (HAMD-24) was administered to evaluate the depressive symptoms. Generalized linear regression, logistic regression and restricted cubic spline models were used to examine the association of serum Cys C levels with depressive symptoms and suicidal ideation. Results Serum Cys C levels were higher in MDD patients than in controls (p = 0.001) and were positively associated with scores on HAMD-24 in unadjusted (gender distribution, age, smoking, alcohol consumption, family history of depression and traumatic life events; (p = 0.003) and fully adjusted linear regression model (p = 0.005). The fully adjusted regression coefficient with 95% confidence intervals for serum Cys C levels and HAMD-24 score was 30.339 (9.602 to 51.077). The level of Cys C in the suicidal ideation (SI) group was significantly higher than that in the non-suicide ideation (non-SI) group (p = 0.001). Serum Cys C levels were positively associated with suicidal ideation in each logistic regression model (all p < 0.05). Conclusion Serum Cys C levels were elevated in MDD patients and appeared to be positively correlated with depressive symptoms and suicidal ideation. These findings suggest that the dysfunction of Cys C may be involved in the severity of depression and in the pathophysiological process of MDD. Thus, regulation of serum Cys C could potentially be an effective predictor of the severity of depression and potentially, play a role in reducing the risk of suicide in MDD patients.Ting SunQian ChenYan LiBMCarticleDepressionSerumCystatin CDepressive symptomsSuicidal ideationPsychiatryRC435-571ENBMC Psychiatry, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Depression Serum Cystatin C Depressive symptoms Suicidal ideation Psychiatry RC435-571
spellingShingle	Depression Serum Cystatin C Depressive symptoms Suicidal ideation Psychiatry RC435-571 Ting Sun Qian Chen Yan Li Associations of serum cystatin C with depressive symptoms and suicidal ideation in major depressive disorder
description	Abstract Background Individuals with major depressive disorder (MDD) have high suicidal ideation. There is evidence that serum cystatin C (Cys C) may be involved in the pathophysiology of MDD. The present study aimed to investigate Cys C concentration in patients with MDD and clarify its possible association with depressive symptoms and suicidal ideation. Methods An online cross-sectional survey of 159 patients diagnosed with MDD was conducted. Serum Cys C levels were measured using ADVIA 2400 biochemical analyzer. The 24-item Hamilton Depression Scale (HAMD-24) was administered to evaluate the depressive symptoms. Generalized linear regression, logistic regression and restricted cubic spline models were used to examine the association of serum Cys C levels with depressive symptoms and suicidal ideation. Results Serum Cys C levels were higher in MDD patients than in controls (p = 0.001) and were positively associated with scores on HAMD-24 in unadjusted (gender distribution, age, smoking, alcohol consumption, family history of depression and traumatic life events; (p = 0.003) and fully adjusted linear regression model (p = 0.005). The fully adjusted regression coefficient with 95% confidence intervals for serum Cys C levels and HAMD-24 score was 30.339 (9.602 to 51.077). The level of Cys C in the suicidal ideation (SI) group was significantly higher than that in the non-suicide ideation (non-SI) group (p = 0.001). Serum Cys C levels were positively associated with suicidal ideation in each logistic regression model (all p < 0.05). Conclusion Serum Cys C levels were elevated in MDD patients and appeared to be positively correlated with depressive symptoms and suicidal ideation. These findings suggest that the dysfunction of Cys C may be involved in the severity of depression and in the pathophysiological process of MDD. Thus, regulation of serum Cys C could potentially be an effective predictor of the severity of depression and potentially, play a role in reducing the risk of suicide in MDD patients.
format	article
author	Ting Sun Qian Chen Yan Li
author_facet	Ting Sun Qian Chen Yan Li
author_sort	Ting Sun
title	Associations of serum cystatin C with depressive symptoms and suicidal ideation in major depressive disorder
title_short	Associations of serum cystatin C with depressive symptoms and suicidal ideation in major depressive disorder
title_full	Associations of serum cystatin C with depressive symptoms and suicidal ideation in major depressive disorder
title_fullStr	Associations of serum cystatin C with depressive symptoms and suicidal ideation in major depressive disorder
title_full_unstemmed	Associations of serum cystatin C with depressive symptoms and suicidal ideation in major depressive disorder
title_sort	associations of serum cystatin c with depressive symptoms and suicidal ideation in major depressive disorder
publisher	BMC
publishDate	2021
url	https://doaj.org/article/b54bfac2d25246b8bbd044dac23d5944
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Associations of serum cystatin C with depressive symptoms and suicidal ideation in major depressive disorder

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