Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis

ASXL1 gene is often mutated in myeloid malignancies. Here, the authors show that mutant ASXL1 and BAP1 are in a positive feedback loop such that BAP1 induces monoubiquitination of mutant ASXL1, which in turn enhances BAP1 activity to potentiate myeloid transformation via HOXA clusters and IRF8.

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Autores principales:	Shuhei Asada, Susumu Goyama, Daichi Inoue, Shiori Shikata, Reina Takeda, Tsuyoshi Fukushima, Taishi Yonezawa, Takeshi Fujino, Yasutaka Hayashi, Kimihito Cojin Kawabata, Tomofusa Fukuyama, Yosuke Tanaka, Akihiko Yokoyama, Satoshi Yamazaki, Hiroko Kozuka-Hata, Masaaki Oyama, Shinya Kojima, Masahito Kawazu, Hiroyuki Mano, Toshio Kitamura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b54c40c22a2a4a1b8cfc19f69a4b3607
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spelling	oai:doaj.org-article:b54c40c22a2a4a1b8cfc19f69a4b36072021-12-02T16:56:41ZMutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis10.1038/s41467-018-05085-92041-1723https://doaj.org/article/b54c40c22a2a4a1b8cfc19f69a4b36072018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05085-9https://doaj.org/toc/2041-1723ASXL1 gene is often mutated in myeloid malignancies. Here, the authors show that mutant ASXL1 and BAP1 are in a positive feedback loop such that BAP1 induces monoubiquitination of mutant ASXL1, which in turn enhances BAP1 activity to potentiate myeloid transformation via HOXA clusters and IRF8.Shuhei AsadaSusumu GoyamaDaichi InoueShiori ShikataReina TakedaTsuyoshi FukushimaTaishi YonezawaTakeshi FujinoYasutaka HayashiKimihito Cojin KawabataTomofusa FukuyamaYosuke TanakaAkihiko YokoyamaSatoshi YamazakiHiroko Kozuka-HataMasaaki OyamaShinya KojimaMasahito KawazuHiroyuki ManoToshio KitamuraNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuhei Asada Susumu Goyama Daichi Inoue Shiori Shikata Reina Takeda Tsuyoshi Fukushima Taishi Yonezawa Takeshi Fujino Yasutaka Hayashi Kimihito Cojin Kawabata Tomofusa Fukuyama Yosuke Tanaka Akihiko Yokoyama Satoshi Yamazaki Hiroko Kozuka-Hata Masaaki Oyama Shinya Kojima Masahito Kawazu Hiroyuki Mano Toshio Kitamura Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis
description	ASXL1 gene is often mutated in myeloid malignancies. Here, the authors show that mutant ASXL1 and BAP1 are in a positive feedback loop such that BAP1 induces monoubiquitination of mutant ASXL1, which in turn enhances BAP1 activity to potentiate myeloid transformation via HOXA clusters and IRF8.
format	article
author	Shuhei Asada Susumu Goyama Daichi Inoue Shiori Shikata Reina Takeda Tsuyoshi Fukushima Taishi Yonezawa Takeshi Fujino Yasutaka Hayashi Kimihito Cojin Kawabata Tomofusa Fukuyama Yosuke Tanaka Akihiko Yokoyama Satoshi Yamazaki Hiroko Kozuka-Hata Masaaki Oyama Shinya Kojima Masahito Kawazu Hiroyuki Mano Toshio Kitamura
author_facet	Shuhei Asada Susumu Goyama Daichi Inoue Shiori Shikata Reina Takeda Tsuyoshi Fukushima Taishi Yonezawa Takeshi Fujino Yasutaka Hayashi Kimihito Cojin Kawabata Tomofusa Fukuyama Yosuke Tanaka Akihiko Yokoyama Satoshi Yamazaki Hiroko Kozuka-Hata Masaaki Oyama Shinya Kojima Masahito Kawazu Hiroyuki Mano Toshio Kitamura
author_sort	Shuhei Asada
title	Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis
title_short	Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis
title_full	Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis
title_fullStr	Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis
title_full_unstemmed	Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis
title_sort	mutant asxl1 cooperates with bap1 to promote myeloid leukaemogenesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b54c40c22a2a4a1b8cfc19f69a4b3607
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Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis

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