Functional competence of a partially engaged GPCR–β-arrestin complex
β-arrestins initially contact with the phosphorylated carboxyl-terminus of GPCRs before engaging with the GPCR core. Here, the authors use a chimeric GPCR partially and fully engaged with β-arrestin1 and show that the core interaction is dispensable for receptor endocytosis and signalling.
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Nature Portfolio
2016
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oai:doaj.org-article:b54ea5ad8c474cb084f9f6760eb120812021-12-02T14:39:50ZFunctional competence of a partially engaged GPCR–β-arrestin complex10.1038/ncomms134162041-1723https://doaj.org/article/b54ea5ad8c474cb084f9f6760eb120812016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13416https://doaj.org/toc/2041-1723β-arrestins initially contact with the phosphorylated carboxyl-terminus of GPCRs before engaging with the GPCR core. Here, the authors use a chimeric GPCR partially and fully engaged with β-arrestin1 and show that the core interaction is dispensable for receptor endocytosis and signalling.Punita KumariAshish SrivastavaRamanuj BanerjeeEshan GhoshPragya GuptaRavi RanjanXin ChenBhagyashri GuptaCharu GuptaDeepika JaimanArun K. ShuklaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Punita Kumari Ashish Srivastava Ramanuj Banerjee Eshan Ghosh Pragya Gupta Ravi Ranjan Xin Chen Bhagyashri Gupta Charu Gupta Deepika Jaiman Arun K. Shukla Functional competence of a partially engaged GPCR–β-arrestin complex |
| description |
β-arrestins initially contact with the phosphorylated carboxyl-terminus of GPCRs before engaging with the GPCR core. Here, the authors use a chimeric GPCR partially and fully engaged with β-arrestin1 and show that the core interaction is dispensable for receptor endocytosis and signalling. |
| format |
article |
| author |
Punita Kumari Ashish Srivastava Ramanuj Banerjee Eshan Ghosh Pragya Gupta Ravi Ranjan Xin Chen Bhagyashri Gupta Charu Gupta Deepika Jaiman Arun K. Shukla |
| author_facet |
Punita Kumari Ashish Srivastava Ramanuj Banerjee Eshan Ghosh Pragya Gupta Ravi Ranjan Xin Chen Bhagyashri Gupta Charu Gupta Deepika Jaiman Arun K. Shukla |
| author_sort |
Punita Kumari |
| title |
Functional competence of a partially engaged GPCR–β-arrestin complex |
| title_short |
Functional competence of a partially engaged GPCR–β-arrestin complex |
| title_full |
Functional competence of a partially engaged GPCR–β-arrestin complex |
| title_fullStr |
Functional competence of a partially engaged GPCR–β-arrestin complex |
| title_full_unstemmed |
Functional competence of a partially engaged GPCR–β-arrestin complex |
| title_sort |
functional competence of a partially engaged gpcr–β-arrestin complex |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/b54ea5ad8c474cb084f9f6760eb12081 |
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| _version_ |
1718390496386088960 |