Is the incidence of anaplastic thyroid cancer increasing: A population based epidemiology study

Objective: To provide an understanding of the incidence of anaplastic thyroid cancer within the United States. Methods: Patients in the Surveillance, Epidemiology, and End Results (SEER) database were included from 1973 to 2014 based on a diagnosis of anaplastic thyroid cancer using ICD O-3 codes. P...

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Autores principales:	Tyler A. Janz, David M. Neskey, Shaun A. Nguyen, Eric J. Lentsch
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2019
Materias:	Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/b554ae9fe19242349b19d56ef1efd0ab
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spelling	oai:doaj.org-article:b554ae9fe19242349b19d56ef1efd0ab2021-12-02T12:53:46ZIs the incidence of anaplastic thyroid cancer increasing: A population based epidemiology study2095-881110.1016/j.wjorl.2018.05.006https://doaj.org/article/b554ae9fe19242349b19d56ef1efd0ab2019-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881118300374https://doaj.org/toc/2095-8811Objective: To provide an understanding of the incidence of anaplastic thyroid cancer within the United States. Methods: Patients in the Surveillance, Epidemiology, and End Results (SEER) database were included from 1973 to 2014 based on a diagnosis of anaplastic thyroid cancer using ICD O-3 codes. Patients were categorized into cohorts based on their year of diagnosis. Results: 1527 patients were diagnosed with anaplastic thyroid cancer within the SEER 18 registries. The age-adjusted incidence rate was 0.2 per 1,000,000 people (95% CI: 0.0–0.5) in 1973 and was 1.2 per 1,000,000 people (95% CI: 0.8–1.6) in 2014 (average annual percent change: 3.0% [95% CI: 2.2%–3.7%]). Patients tended to be of older age (mean age: 70.5 [range 15.0–102.0]), of female sex (62.8%), and Caucasian (81.1%). Finally, survival over time remained the same, as median disease specific survival months was 4.00 (95% CI: 2.26–5.74) from 1995 to 1999 and 4.00 (95% CI: 3.26–4.74) from 2010 to 2014. Conclusions: The incidence rate of anaplastic thyroid cancer has increased from 1973 to 2014. Interestingly, median survival in months did not greatly change overtime. Based on this increasing incidence, physicians must act appropriately to identify patients with anaplastic thyroid cancer as it possesses a high morbidity and mortality. Level of evidence: 4. Keywords: Anaplastic thyroid cancer, Thyroid cancer, Head and neck, Head and neck endocrine surgery, Head and neck oncologyTyler A. JanzDavid M. NeskeyShaun A. NguyenEric J. LentschKeAi Communications Co., Ltd.articleOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 5, Iss 1, Pp 34-40 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Otorhinolaryngology RF1-547 Surgery RD1-811 Tyler A. Janz David M. Neskey Shaun A. Nguyen Eric J. Lentsch Is the incidence of anaplastic thyroid cancer increasing: A population based epidemiology study
description	Objective: To provide an understanding of the incidence of anaplastic thyroid cancer within the United States. Methods: Patients in the Surveillance, Epidemiology, and End Results (SEER) database were included from 1973 to 2014 based on a diagnosis of anaplastic thyroid cancer using ICD O-3 codes. Patients were categorized into cohorts based on their year of diagnosis. Results: 1527 patients were diagnosed with anaplastic thyroid cancer within the SEER 18 registries. The age-adjusted incidence rate was 0.2 per 1,000,000 people (95% CI: 0.0–0.5) in 1973 and was 1.2 per 1,000,000 people (95% CI: 0.8–1.6) in 2014 (average annual percent change: 3.0% [95% CI: 2.2%–3.7%]). Patients tended to be of older age (mean age: 70.5 [range 15.0–102.0]), of female sex (62.8%), and Caucasian (81.1%). Finally, survival over time remained the same, as median disease specific survival months was 4.00 (95% CI: 2.26–5.74) from 1995 to 1999 and 4.00 (95% CI: 3.26–4.74) from 2010 to 2014. Conclusions: The incidence rate of anaplastic thyroid cancer has increased from 1973 to 2014. Interestingly, median survival in months did not greatly change overtime. Based on this increasing incidence, physicians must act appropriately to identify patients with anaplastic thyroid cancer as it possesses a high morbidity and mortality. Level of evidence: 4. Keywords: Anaplastic thyroid cancer, Thyroid cancer, Head and neck, Head and neck endocrine surgery, Head and neck oncology
format	article
author	Tyler A. Janz David M. Neskey Shaun A. Nguyen Eric J. Lentsch
author_facet	Tyler A. Janz David M. Neskey Shaun A. Nguyen Eric J. Lentsch
author_sort	Tyler A. Janz
title	Is the incidence of anaplastic thyroid cancer increasing: A population based epidemiology study
title_short	Is the incidence of anaplastic thyroid cancer increasing: A population based epidemiology study
title_full	Is the incidence of anaplastic thyroid cancer increasing: A population based epidemiology study
title_fullStr	Is the incidence of anaplastic thyroid cancer increasing: A population based epidemiology study
title_full_unstemmed	Is the incidence of anaplastic thyroid cancer increasing: A population based epidemiology study
title_sort	is the incidence of anaplastic thyroid cancer increasing: a population based epidemiology study
publisher	KeAi Communications Co., Ltd.
publishDate	2019
url	https://doaj.org/article/b554ae9fe19242349b19d56ef1efd0ab
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Is the incidence of anaplastic thyroid cancer increasing: A population based epidemiology study

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