Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection

Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection

Sex differences in the immune response to vaccines and infections have been well described in children and adults. Here the authors describe, in a cohort of 177 HIV-infected infants, innate immune sex differences in fetal life that increase female susceptibility to intrauterine HIV infection and inc...

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Autores principales: Emily Adland, Jane Millar, Nomonde Bengu, Maximilian Muenchhoff, Rowena Fillis, Kenneth Sprenger, Vuyokasi Ntlantsana, Julia Roider, Vinicius Vieira, Katya Govender, John Adamson, Nelisiwe Nxele, Christina Ochsenbauer, John Kappes, Luisa Mori, Jeroen van Lobenstein, Yeney Graza, Kogielambal Chinniah, Constant Kapongo, Roopesh Bhoola, Malini Krishna, Philippa C. Matthews, Ruth Penya Poderos, Marta Colomer Lluch, Maria C. Puertas, Julia G. Prado, Neil McKerrow, Moherndran Archary, Thumbi Ndung’u, Andreas Groll, Pieter Jooste, Javier Martinez-Picado, Marcus Altfeld, Philip Goulder
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b55696a6d6ee44ba9f20d18889681d90
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spelling oai:doaj.org-article:b55696a6d6ee44ba9f20d18889681d902021-12-02T17:31:54ZSex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection10.1038/s41467-020-15632-y2041-1723https://doaj.org/article/b55696a6d6ee44ba9f20d18889681d902020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15632-yhttps://doaj.org/toc/2041-1723Sex differences in the immune response to vaccines and infections have been well described in children and adults. Here the authors describe, in a cohort of 177 HIV-infected infants, innate immune sex differences in fetal life that increase female susceptibility to intrauterine HIV infection and increase the chances of subsequent HIV remission in infected males.Emily AdlandJane MillarNomonde BenguMaximilian MuenchhoffRowena FillisKenneth SprengerVuyokasi NtlantsanaJulia RoiderVinicius VieiraKatya GovenderJohn AdamsonNelisiwe NxeleChristina OchsenbauerJohn KappesLuisa MoriJeroen van LobensteinYeney GrazaKogielambal ChinniahConstant KapongoRoopesh BhoolaMalini KrishnaPhilippa C. MatthewsRuth Penya PoderosMarta Colomer LluchMaria C. PuertasJulia G. PradoNeil McKerrowMoherndran ArcharyThumbi Ndung’uAndreas GrollPieter JoosteJavier Martinez-PicadoMarcus AltfeldPhilip GoulderNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Emily Adland
Jane Millar
Nomonde Bengu
Maximilian Muenchhoff
Rowena Fillis
Kenneth Sprenger
Vuyokasi Ntlantsana
Julia Roider
Vinicius Vieira
Katya Govender
John Adamson
Nelisiwe Nxele
Christina Ochsenbauer
John Kappes
Luisa Mori
Jeroen van Lobenstein
Yeney Graza
Kogielambal Chinniah
Constant Kapongo
Roopesh Bhoola
Malini Krishna
Philippa C. Matthews
Ruth Penya Poderos
Marta Colomer Lluch
Maria C. Puertas
Julia G. Prado
Neil McKerrow
Moherndran Archary
Thumbi Ndung’u
Andreas Groll
Pieter Jooste
Javier Martinez-Picado
Marcus Altfeld
Philip Goulder
Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection
description Sex differences in the immune response to vaccines and infections have been well described in children and adults. Here the authors describe, in a cohort of 177 HIV-infected infants, innate immune sex differences in fetal life that increase female susceptibility to intrauterine HIV infection and increase the chances of subsequent HIV remission in infected males.
format article
author Emily Adland
Jane Millar
Nomonde Bengu
Maximilian Muenchhoff
Rowena Fillis
Kenneth Sprenger
Vuyokasi Ntlantsana
Julia Roider
Vinicius Vieira
Katya Govender
John Adamson
Nelisiwe Nxele
Christina Ochsenbauer
John Kappes
Luisa Mori
Jeroen van Lobenstein
Yeney Graza
Kogielambal Chinniah
Constant Kapongo
Roopesh Bhoola
Malini Krishna
Philippa C. Matthews
Ruth Penya Poderos
Marta Colomer Lluch
Maria C. Puertas
Julia G. Prado
Neil McKerrow
Moherndran Archary
Thumbi Ndung’u
Andreas Groll
Pieter Jooste
Javier Martinez-Picado
Marcus Altfeld
Philip Goulder
author_facet Emily Adland
Jane Millar
Nomonde Bengu
Maximilian Muenchhoff
Rowena Fillis
Kenneth Sprenger
Vuyokasi Ntlantsana
Julia Roider
Vinicius Vieira
Katya Govender
John Adamson
Nelisiwe Nxele
Christina Ochsenbauer
John Kappes
Luisa Mori
Jeroen van Lobenstein
Yeney Graza
Kogielambal Chinniah
Constant Kapongo
Roopesh Bhoola
Malini Krishna
Philippa C. Matthews
Ruth Penya Poderos
Marta Colomer Lluch
Maria C. Puertas
Julia G. Prado
Neil McKerrow
Moherndran Archary
Thumbi Ndung’u
Andreas Groll
Pieter Jooste
Javier Martinez-Picado
Marcus Altfeld
Philip Goulder
author_sort Emily Adland
title Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection
title_short Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection
title_full Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection
title_fullStr Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection
title_full_unstemmed Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection
title_sort sex-specific innate immune selection of hiv-1 in utero is associated with increased female susceptibility to infection
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/b55696a6d6ee44ba9f20d18889681d90
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