Modification of messenger RNA by 2′-O-methylation regulates gene expression in vivo

The post-transcriptional modification of mRNAs provides an additional layer to gene expression regulation. Here the authors show that 2′-O-methylation mediated by box C/D snoRNAs and fibrillarin can inhibit the translation of target mRNAs.

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Autores principales:	Brittany A. Elliott, Hsiang-Ting Ho, Srivathsan V. Ranganathan, Sweta Vangaveti, Olga Ilkayeva, Hala Abou Assi, Alex K. Choi, Paul F. Agris, Christopher L. Holley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b5583f16311b4eff9351aede56bc09e1
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spelling	oai:doaj.org-article:b5583f16311b4eff9351aede56bc09e12021-12-02T15:36:18ZModification of messenger RNA by 2′-O-methylation regulates gene expression in vivo10.1038/s41467-019-11375-72041-1723https://doaj.org/article/b5583f16311b4eff9351aede56bc09e12019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11375-7https://doaj.org/toc/2041-1723The post-transcriptional modification of mRNAs provides an additional layer to gene expression regulation. Here the authors show that 2′-O-methylation mediated by box C/D snoRNAs and fibrillarin can inhibit the translation of target mRNAs.Brittany A. ElliottHsiang-Ting HoSrivathsan V. RanganathanSweta VangavetiOlga IlkayevaHala Abou AssiAlex K. ChoiPaul F. AgrisChristopher L. HolleyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brittany A. Elliott Hsiang-Ting Ho Srivathsan V. Ranganathan Sweta Vangaveti Olga Ilkayeva Hala Abou Assi Alex K. Choi Paul F. Agris Christopher L. Holley Modification of messenger RNA by 2′-O-methylation regulates gene expression in vivo
description	The post-transcriptional modification of mRNAs provides an additional layer to gene expression regulation. Here the authors show that 2′-O-methylation mediated by box C/D snoRNAs and fibrillarin can inhibit the translation of target mRNAs.
format	article
author	Brittany A. Elliott Hsiang-Ting Ho Srivathsan V. Ranganathan Sweta Vangaveti Olga Ilkayeva Hala Abou Assi Alex K. Choi Paul F. Agris Christopher L. Holley
author_facet	Brittany A. Elliott Hsiang-Ting Ho Srivathsan V. Ranganathan Sweta Vangaveti Olga Ilkayeva Hala Abou Assi Alex K. Choi Paul F. Agris Christopher L. Holley
author_sort	Brittany A. Elliott
title	Modification of messenger RNA by 2′-O-methylation regulates gene expression in vivo
title_short	Modification of messenger RNA by 2′-O-methylation regulates gene expression in vivo
title_full	Modification of messenger RNA by 2′-O-methylation regulates gene expression in vivo
title_fullStr	Modification of messenger RNA by 2′-O-methylation regulates gene expression in vivo
title_full_unstemmed	Modification of messenger RNA by 2′-O-methylation regulates gene expression in vivo
title_sort	modification of messenger rna by 2′-o-methylation regulates gene expression in vivo
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b5583f16311b4eff9351aede56bc09e1
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Modification of messenger RNA by 2′-O-methylation regulates gene expression in vivo

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