Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis

The combination of intermittent fasting and chemotherapy can improve the response to treatment. Here, the authors show that SIRT7 activation is required to inactivate Akt during intermittent fasting and that the combination of intermittent fasting and inhibitors that block the Erk pathway can improv...

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Autores principales:	Xiaolong Tang, Guo Li, Lei Shi, Fengting Su, Minxian Qian, Zuojun Liu, Yuan Meng, Shimin Sun, Ji Li, Baohua Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b558c32cb2f94905887f6a978bd50b73
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spelling	oai:doaj.org-article:b558c32cb2f94905887f6a978bd50b732021-12-02T19:02:36ZCombined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis10.1038/s41467-021-25274-32041-1723https://doaj.org/article/b558c32cb2f94905887f6a978bd50b732021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25274-3https://doaj.org/toc/2041-1723The combination of intermittent fasting and chemotherapy can improve the response to treatment. Here, the authors show that SIRT7 activation is required to inactivate Akt during intermittent fasting and that the combination of intermittent fasting and inhibitors that block the Erk pathway can improve efficacy of treatment.Xiaolong TangGuo LiLei ShiFengting SuMinxian QianZuojun LiuYuan MengShimin SunJi LiBaohua LiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaolong Tang Guo Li Lei Shi Fengting Su Minxian Qian Zuojun Liu Yuan Meng Shimin Sun Ji Li Baohua Liu Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis
description	The combination of intermittent fasting and chemotherapy can improve the response to treatment. Here, the authors show that SIRT7 activation is required to inactivate Akt during intermittent fasting and that the combination of intermittent fasting and inhibitors that block the Erk pathway can improve efficacy of treatment.
format	article
author	Xiaolong Tang Guo Li Lei Shi Fengting Su Minxian Qian Zuojun Liu Yuan Meng Shimin Sun Ji Li Baohua Liu
author_facet	Xiaolong Tang Guo Li Lei Shi Fengting Su Minxian Qian Zuojun Liu Yuan Meng Shimin Sun Ji Li Baohua Liu
author_sort	Xiaolong Tang
title	Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis
title_short	Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis
title_full	Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis
title_fullStr	Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis
title_full_unstemmed	Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis
title_sort	combined intermittent fasting and erk inhibition enhance the anti-tumor effects of chemotherapy via the gsk3β-sirt7 axis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b558c32cb2f94905887f6a978bd50b73
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Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis

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