Coexpression of ΔNp63/p40 and TTF1 Within Most of the Same Individual Cells Identifies Life-Threatening NSCLC Featuring Squamous and Glandular Biphenotypic Differentiation: Clinicopathologic Correlations

Coexpression of ΔNp63/p40 and TTF1 Within Most of the Same Individual Cells Identifies Life-Threatening NSCLC Featuring Squamous and Glandular Biphenotypic Differentiation: Clinicopathologic Correlations

Introduction: Double occurrence of TTF1 and ΔNp63/p40 (henceforth, p40) within the same individual cells is exceedingly rare in lung cancer. Little is known on their biological and clinical implications. Methods: Two index cases immunoreactive for both p40 and TTF1 and nine tumors selected from The...

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Autores principales: Giuseppe Pelosi, MD, MIAC, Matteo Bulloni, PhD, Martina Vescio, PhD, Silvia Uccella, MD, Fabien Forest, MD, Giorgia Leone, MD, Massimo Barberis, MD, Daoud Rahal, MD, Paola Bossi, MD, Giovanna Finzi, MD, Deborah Marchiori, MD, Marco De Luca, MD, Fausto Sessa, MD, Sergio Harari, MD, Manuela Spinelli, MD, Patrizia Viola, MD, Paolo Macrì, MD, Stefania Maria, MD, Antonio Rizzo, MD, Antonio Picone, MD, Linda Pattini, PhD
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
ΔNp63/p40
TTF-1
Lung
Non–small cell carcinoma
Prognosis
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/b5599054993748b39c6aa8019d597ff7
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