The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells

Although micro(mi)RNA-based post-transcriptional regulatory mechanisms have been implicated in the assembly and modulation of synaptic connections, few miRNAs have been identified that control synapse formation. Here, authors performed an unbiased screen for novel regulators of synapse morphogenesis...

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Autores principales:	Elizabeth M. McNeill, Chloe Warinner, Stephen Alkins, Alicia Taylor, Hansine Heggeness, Todd F. DeLuca, Tudor A. Fulga, Dennis P. Wall, Leslie C. Griffith, David Van Vactor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b55a3441b07e4959ac857894059e3df7
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spelling	oai:doaj.org-article:b55a3441b07e4959ac857894059e3df72021-12-02T15:34:14ZThe conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells10.1038/s41467-020-14761-82041-1723https://doaj.org/article/b55a3441b07e4959ac857894059e3df72020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14761-8https://doaj.org/toc/2041-1723Although micro(mi)RNA-based post-transcriptional regulatory mechanisms have been implicated in the assembly and modulation of synaptic connections, few miRNAs have been identified that control synapse formation. Here, authors performed an unbiased screen for novel regulators of synapse morphogenesis at the Drosophila larval neuromuscular junction and discovered that miR-34 inhibits Nrx-IV to influence active zone formation, whereas, postsynaptic miR-34 inhibits Hts to regulate the initiation of bouton formation from presynaptic terminals.Elizabeth M. McNeillChloe WarinnerStephen AlkinsAlicia TaylorHansine HeggenessTodd F. DeLucaTudor A. FulgaDennis P. WallLeslie C. GriffithDavid Van VactorNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elizabeth M. McNeill Chloe Warinner Stephen Alkins Alicia Taylor Hansine Heggeness Todd F. DeLuca Tudor A. Fulga Dennis P. Wall Leslie C. Griffith David Van Vactor The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells
description	Although micro(mi)RNA-based post-transcriptional regulatory mechanisms have been implicated in the assembly and modulation of synaptic connections, few miRNAs have been identified that control synapse formation. Here, authors performed an unbiased screen for novel regulators of synapse morphogenesis at the Drosophila larval neuromuscular junction and discovered that miR-34 inhibits Nrx-IV to influence active zone formation, whereas, postsynaptic miR-34 inhibits Hts to regulate the initiation of bouton formation from presynaptic terminals.
format	article
author	Elizabeth M. McNeill Chloe Warinner Stephen Alkins Alicia Taylor Hansine Heggeness Todd F. DeLuca Tudor A. Fulga Dennis P. Wall Leslie C. Griffith David Van Vactor
author_facet	Elizabeth M. McNeill Chloe Warinner Stephen Alkins Alicia Taylor Hansine Heggeness Todd F. DeLuca Tudor A. Fulga Dennis P. Wall Leslie C. Griffith David Van Vactor
author_sort	Elizabeth M. McNeill
title	The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells
title_short	The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells
title_full	The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells
title_fullStr	The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells
title_full_unstemmed	The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells
title_sort	conserved microrna mir-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b55a3441b07e4959ac857894059e3df7
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The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells

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