Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm

Translocation of (6;8)(p21;q24), a recurrent abnormality of blastic plasmacytoid dendritic cell neoplasm, involves adjacent MYC and RUNX2 regions. Here, the authors show that the RUNX2 super-enhancer is hijacked to activate MYC in addition to RUNX2 expression, promoting the development of this cance...

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Autores principales:	Sho Kubota, Kenji Tokunaga, Tomohiro Umezu, Takako Yokomizo-Nakano, Yuqi Sun, Motohiko Oshima, Kar Tong Tan, Henry Yang, Akinori Kanai, Eisaku Iwanaga, Norio Asou, Takahiro Maeda, Naomi Nakagata, Atsushi Iwama, Kazuma Ohyashiki, Motomi Osato, Goro Sashida
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b55f6237adba4583b97db796afe3c64f
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spelling	oai:doaj.org-article:b55f6237adba4583b97db796afe3c64f2021-12-02T15:35:37ZLineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm10.1038/s41467-019-09710-z2041-1723https://doaj.org/article/b55f6237adba4583b97db796afe3c64f2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09710-zhttps://doaj.org/toc/2041-1723Translocation of (6;8)(p21;q24), a recurrent abnormality of blastic plasmacytoid dendritic cell neoplasm, involves adjacent MYC and RUNX2 regions. Here, the authors show that the RUNX2 super-enhancer is hijacked to activate MYC in addition to RUNX2 expression, promoting the development of this cancer.Sho KubotaKenji TokunagaTomohiro UmezuTakako Yokomizo-NakanoYuqi SunMotohiko OshimaKar Tong TanHenry YangAkinori KanaiEisaku IwanagaNorio AsouTakahiro MaedaNaomi NakagataAtsushi IwamaKazuma OhyashikiMotomi OsatoGoro SashidaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sho Kubota Kenji Tokunaga Tomohiro Umezu Takako Yokomizo-Nakano Yuqi Sun Motohiko Oshima Kar Tong Tan Henry Yang Akinori Kanai Eisaku Iwanaga Norio Asou Takahiro Maeda Naomi Nakagata Atsushi Iwama Kazuma Ohyashiki Motomi Osato Goro Sashida Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm
description	Translocation of (6;8)(p21;q24), a recurrent abnormality of blastic plasmacytoid dendritic cell neoplasm, involves adjacent MYC and RUNX2 regions. Here, the authors show that the RUNX2 super-enhancer is hijacked to activate MYC in addition to RUNX2 expression, promoting the development of this cancer.
format	article
author	Sho Kubota Kenji Tokunaga Tomohiro Umezu Takako Yokomizo-Nakano Yuqi Sun Motohiko Oshima Kar Tong Tan Henry Yang Akinori Kanai Eisaku Iwanaga Norio Asou Takahiro Maeda Naomi Nakagata Atsushi Iwama Kazuma Ohyashiki Motomi Osato Goro Sashida
author_facet	Sho Kubota Kenji Tokunaga Tomohiro Umezu Takako Yokomizo-Nakano Yuqi Sun Motohiko Oshima Kar Tong Tan Henry Yang Akinori Kanai Eisaku Iwanaga Norio Asou Takahiro Maeda Naomi Nakagata Atsushi Iwama Kazuma Ohyashiki Motomi Osato Goro Sashida
author_sort	Sho Kubota
title	Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm
title_short	Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm
title_full	Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm
title_fullStr	Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm
title_full_unstemmed	Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm
title_sort	lineage-specific runx2 super-enhancer activates myc and promotes the development of blastic plasmacytoid dendritic cell neoplasm
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b55f6237adba4583b97db796afe3c64f
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Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm

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