Evolution of HER2-positive mammary carcinoma: HER2 loss reveals claudin-low traits in cancer progression

Evolution of HER2-positive mammary carcinoma: HER2 loss reveals claudin-low traits in cancer progression

Abstract HER2-positive breast cancers may lose HER2 expression in recurrences and metastases. In this work, we studied cell lines derived from two transgenic mammary tumors driven by human HER2 that showed different dynamics of HER2 status. MamBo89HER2 stable cell line displayed high and stable HER2...

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Bibliographic Details
Main Authors: Veronica Giusti, Francesca Ruzzi, Lorena Landuzzi, Marianna L. Ianzano, Roberta Laranga, Elena Nironi, Laura Scalambra, Giordano Nicoletti, Carla De Giovanni, Martina Olivero, Maddalena Arigoni, Raffaele Calogero, Patrizia Nanni, Arianna Palladini, Pier-Luigi Lollini
Format: article
Language:EN
Published: Nature Publishing Group 2021
Subjects:
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/b560bd2ffc044642b16dd92b9b06a0fa
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https://doaj.org/article/b560bd2ffc044642b16dd92b9b06a0fa

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