EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance

Ephrins are transmembrane proteins involved in cell-cell communication, and implicated in cancer cell growth and progression. Here, the authors show that EphrinB2 expression is reduced in glioma cells both by genetic and epigenetic alterations and under hypoxia, through a HIF1α-mediated direct regul...

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Autores principales:	C. Depner, H. zum Buttel, N. Böğürcü, A. M. Cuesta, M. R. Aburto, S. Seidel, F. Finkelmeier, F. Foss, J. Hofmann, K. Kaulich, S. Barbus, M. Segarra, G. Reifenberger, B. K. Garvalov, T. Acker, A. Acker-Palmer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b5621b9d2c974229858dc255a24f288b
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spelling	oai:doaj.org-article:b5621b9d2c974229858dc255a24f288b2021-12-02T15:34:09ZEphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance10.1038/ncomms123292041-1723https://doaj.org/article/b5621b9d2c974229858dc255a24f288b2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12329https://doaj.org/toc/2041-1723Ephrins are transmembrane proteins involved in cell-cell communication, and implicated in cancer cell growth and progression. Here, the authors show that EphrinB2 expression is reduced in glioma cells both by genetic and epigenetic alterations and under hypoxia, through a HIF1α-mediated direct regulation of ZEB2, which enhances invasion and anti-angiogenic resistance.C. DepnerH. zum ButtelN. BöğürcüA. M. CuestaM. R. AburtoS. SeidelF. FinkelmeierF. FossJ. HofmannK. KaulichS. BarbusM. SegarraG. ReifenbergerB. K. GarvalovT. AckerA. Acker-PalmerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q C. Depner H. zum Buttel N. Böğürcü A. M. Cuesta M. R. Aburto S. Seidel F. Finkelmeier F. Foss J. Hofmann K. Kaulich S. Barbus M. Segarra G. Reifenberger B. K. Garvalov T. Acker A. Acker-Palmer EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance
description	Ephrins are transmembrane proteins involved in cell-cell communication, and implicated in cancer cell growth and progression. Here, the authors show that EphrinB2 expression is reduced in glioma cells both by genetic and epigenetic alterations and under hypoxia, through a HIF1α-mediated direct regulation of ZEB2, which enhances invasion and anti-angiogenic resistance.
format	article
author	C. Depner H. zum Buttel N. Böğürcü A. M. Cuesta M. R. Aburto S. Seidel F. Finkelmeier F. Foss J. Hofmann K. Kaulich S. Barbus M. Segarra G. Reifenberger B. K. Garvalov T. Acker A. Acker-Palmer
author_facet	C. Depner H. zum Buttel N. Böğürcü A. M. Cuesta M. R. Aburto S. Seidel F. Finkelmeier F. Foss J. Hofmann K. Kaulich S. Barbus M. Segarra G. Reifenberger B. K. Garvalov T. Acker A. Acker-Palmer
author_sort	C. Depner
title	EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance
title_short	EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance
title_full	EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance
title_fullStr	EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance
title_full_unstemmed	EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance
title_sort	ephrinb2 repression through zeb2 mediates tumour invasion and anti-angiogenic resistance
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b5621b9d2c974229858dc255a24f288b
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EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance

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