PREDICTION OF CLINICAL EFFICIENCY OF SIMVASTATIN TREATMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS

Abstract. Treatment with statins results in reduction of disease activity in one-third of patients with rheumatoid arthritis (RA). The aim of this study was to assess some factors that may predict clinical response to simvastatin therapy before starting the treatment. We evaluated an association of...

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Autores principales:	I. V. Shirinsky, V. S. Shirinsky
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	rheumatoid arthritis prediction of clinical efficiency treatment statins Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b56b4214ffd748fca7ef097d9719f393
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spelling	oai:doaj.org-article:b56b4214ffd748fca7ef097d9719f3932021-11-18T08:03:40ZPREDICTION OF CLINICAL EFFICIENCY OF SIMVASTATIN TREATMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS1563-06252313-741X10.15789/1563-0625-2009-2-3-221-226https://doaj.org/article/b56b4214ffd748fca7ef097d9719f3932014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/306https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Treatment with statins results in reduction of disease activity in one-third of patients with rheumatoid arthritis (RA). The aim of this study was to assess some factors that may predict clinical response to simvastatin therapy before starting the treatment. We evaluated an association of treatment efficacy with baseline clinical and laboratory parameters including disease activity measures, cytokine profiles in sera and culture supernatants of peripheral blood mononuclear cells. Thirty-three patients with active RA were enrolled in the study. The patients were treated with simvastatin at 40 mg/day for three months. Eleven patients (33%) developed a moderate response according to EULAR criteria. It was shown that serum IL-10 concentrations was higher in responders, and positively correlated with clinical response to simvastatin. We carried out a receiver operating characteristic curve (ROC) analysis in order to assess the accuracy of serum IL-10 for the predicting of EULAR response development. The cut-off threshold corresponding to the highest sensitivity (89%) and specificity (62%) was a value of 6.5 pg/ml. In conclusion, the performance characteristics of serum IL-10 measurement proved to be good enough to predict EULAR response to simvastatin therapy in RA patients.I. V. ShirinskyV. S. ShirinskySPb RAACIarticlerheumatoid arthritisprediction of clinical efficiencytreatmentstatinsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 2-3, Pp 221-226 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	rheumatoid arthritis prediction of clinical efficiency treatment statins Immunologic diseases. Allergy RC581-607
spellingShingle	rheumatoid arthritis prediction of clinical efficiency treatment statins Immunologic diseases. Allergy RC581-607 I. V. Shirinsky V. S. Shirinsky PREDICTION OF CLINICAL EFFICIENCY OF SIMVASTATIN TREATMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS
description	Abstract. Treatment with statins results in reduction of disease activity in one-third of patients with rheumatoid arthritis (RA). The aim of this study was to assess some factors that may predict clinical response to simvastatin therapy before starting the treatment. We evaluated an association of treatment efficacy with baseline clinical and laboratory parameters including disease activity measures, cytokine profiles in sera and culture supernatants of peripheral blood mononuclear cells. Thirty-three patients with active RA were enrolled in the study. The patients were treated with simvastatin at 40 mg/day for three months. Eleven patients (33%) developed a moderate response according to EULAR criteria. It was shown that serum IL-10 concentrations was higher in responders, and positively correlated with clinical response to simvastatin. We carried out a receiver operating characteristic curve (ROC) analysis in order to assess the accuracy of serum IL-10 for the predicting of EULAR response development. The cut-off threshold corresponding to the highest sensitivity (89%) and specificity (62%) was a value of 6.5 pg/ml. In conclusion, the performance characteristics of serum IL-10 measurement proved to be good enough to predict EULAR response to simvastatin therapy in RA patients.
format	article
author	I. V. Shirinsky V. S. Shirinsky
author_facet	I. V. Shirinsky V. S. Shirinsky
author_sort	I. V. Shirinsky
title	PREDICTION OF CLINICAL EFFICIENCY OF SIMVASTATIN TREATMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS
title_short	PREDICTION OF CLINICAL EFFICIENCY OF SIMVASTATIN TREATMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS
title_full	PREDICTION OF CLINICAL EFFICIENCY OF SIMVASTATIN TREATMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS
title_fullStr	PREDICTION OF CLINICAL EFFICIENCY OF SIMVASTATIN TREATMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS
title_full_unstemmed	PREDICTION OF CLINICAL EFFICIENCY OF SIMVASTATIN TREATMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS
title_sort	prediction of clinical efficiency of simvastatin treatment in patients with rheumatoid arthritis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/b56b4214ffd748fca7ef097d9719f393
work_keys_str_mv	AT ivshirinsky predictionofclinicalefficiencyofsimvastatintreatmentinpatientswithrheumatoidarthritis AT vsshirinsky predictionofclinicalefficiencyofsimvastatintreatmentinpatientswithrheumatoidarthritis
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PREDICTION OF CLINICAL EFFICIENCY OF SIMVASTATIN TREATMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS

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