Chronic mild and acute severe glaucomatous neurodegeneration derived from silicone oil-induced ocular hypertension

Abstract Recently, we established silicone oil-induced ocular hypertension (SOHU) mouse model with significant glaucomatous neurodegeneration. Here we characterize two additional variations of this model that simulate two distinct glaucoma types. The first is a chronic model produced by high frequen...

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Autores principales:	Fang Fang, Jie Zhang, Pei Zhuang, Pingting Liu, Liang Li, Haoliang Huang, Hannah C. Webber, Yangfan Xu, Liang Liu, Roopa Dalal, Yang Sun, Yang Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b56f10aee3c44d8a9baa17bf455794f1
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spelling	oai:doaj.org-article:b56f10aee3c44d8a9baa17bf455794f12021-12-02T16:55:46ZChronic mild and acute severe glaucomatous neurodegeneration derived from silicone oil-induced ocular hypertension10.1038/s41598-021-88690-x2045-2322https://doaj.org/article/b56f10aee3c44d8a9baa17bf455794f12021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88690-xhttps://doaj.org/toc/2045-2322Abstract Recently, we established silicone oil-induced ocular hypertension (SOHU) mouse model with significant glaucomatous neurodegeneration. Here we characterize two additional variations of this model that simulate two distinct glaucoma types. The first is a chronic model produced by high frequency (HF) pupillary dilation after SO-induced pupillary block, which shows sustained moderate IOP elevation and corresponding slow, mild glaucomatous neurodegeneration. We also demonstrate that although SO removal quickly returns IOP to normal, the glaucomatous neurodegeneration continues to advance to a similar degree as in the HF group without SO removal. The second, an acute model created by no pupillary dilation (ND), shows a greatly elevated IOP and severe inner retina degeneration at an early time point. Therefore, by a straightforward dilation scheme, we extend our original SOHU model to recapitulate phenotypes of two major glaucoma forms, which will be invaluable for selecting neuroprotectants and elucidating their molecular mechanisms.Fang FangJie ZhangPei ZhuangPingting LiuLiang LiHaoliang HuangHannah C. WebberYangfan XuLiang LiuRoopa DalalYang SunYang HuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fang Fang Jie Zhang Pei Zhuang Pingting Liu Liang Li Haoliang Huang Hannah C. Webber Yangfan Xu Liang Liu Roopa Dalal Yang Sun Yang Hu Chronic mild and acute severe glaucomatous neurodegeneration derived from silicone oil-induced ocular hypertension
description	Abstract Recently, we established silicone oil-induced ocular hypertension (SOHU) mouse model with significant glaucomatous neurodegeneration. Here we characterize two additional variations of this model that simulate two distinct glaucoma types. The first is a chronic model produced by high frequency (HF) pupillary dilation after SO-induced pupillary block, which shows sustained moderate IOP elevation and corresponding slow, mild glaucomatous neurodegeneration. We also demonstrate that although SO removal quickly returns IOP to normal, the glaucomatous neurodegeneration continues to advance to a similar degree as in the HF group without SO removal. The second, an acute model created by no pupillary dilation (ND), shows a greatly elevated IOP and severe inner retina degeneration at an early time point. Therefore, by a straightforward dilation scheme, we extend our original SOHU model to recapitulate phenotypes of two major glaucoma forms, which will be invaluable for selecting neuroprotectants and elucidating their molecular mechanisms.
format	article
author	Fang Fang Jie Zhang Pei Zhuang Pingting Liu Liang Li Haoliang Huang Hannah C. Webber Yangfan Xu Liang Liu Roopa Dalal Yang Sun Yang Hu
author_facet	Fang Fang Jie Zhang Pei Zhuang Pingting Liu Liang Li Haoliang Huang Hannah C. Webber Yangfan Xu Liang Liu Roopa Dalal Yang Sun Yang Hu
author_sort	Fang Fang
title	Chronic mild and acute severe glaucomatous neurodegeneration derived from silicone oil-induced ocular hypertension
title_short	Chronic mild and acute severe glaucomatous neurodegeneration derived from silicone oil-induced ocular hypertension
title_full	Chronic mild and acute severe glaucomatous neurodegeneration derived from silicone oil-induced ocular hypertension
title_fullStr	Chronic mild and acute severe glaucomatous neurodegeneration derived from silicone oil-induced ocular hypertension
title_full_unstemmed	Chronic mild and acute severe glaucomatous neurodegeneration derived from silicone oil-induced ocular hypertension
title_sort	chronic mild and acute severe glaucomatous neurodegeneration derived from silicone oil-induced ocular hypertension
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b56f10aee3c44d8a9baa17bf455794f1
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Chronic mild and acute severe glaucomatous neurodegeneration derived from silicone oil-induced ocular hypertension

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