Update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients

Adam M Moss, Alon Harris, Brent Siesky, Deepam Rusia, Kathleen M Williamson, Yochai ShoshaniDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USAAbstract: Topical hypotensive therapy with both timolol and carbonic anhydrase inhibitors has been shown to be eff...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Adam M Moss, Alon Harris, Brent Siesky, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/b5724d47208e4770a2269aa2f77c4e8f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b5724d47208e4770a2269aa2f77c4e8f
record_format	dspace
spelling	oai:doaj.org-article:b5724d47208e4770a2269aa2f77c4e8f2021-12-02T00:18:34ZUpdate and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients1177-54671177-5483https://doaj.org/article/b5724d47208e4770a2269aa2f77c4e8f2010-03-01T00:00:00Zhttp://www.dovepress.com/update-and-critical-appraisal-of-combined-timolol-and-carbonic-anhydra-a4154https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Adam M Moss, Alon Harris, Brent Siesky, Deepam Rusia, Kathleen M Williamson, Yochai ShoshaniDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USAAbstract: Topical hypotensive therapy with both timolol and carbonic anhydrase inhibitors has been shown to be efficacious at reducing intraocular pressure. Many prospective studies have also suggested that carbonic anhydrase inhibitors augment ocular blood flow and vascular regulation independent of their hypotensive effects. Although consistent in their findings, these studies must be cautiously interpreted due to the limitations of study design and specific blood flow imaging modalities. The purpose of this review is to appraise and critically evaluate the current body of literature investigating the effects of combined treatment with topical carbonic anhydrase inhibitors and timolol in patients with glaucoma with respect to ocular blood flow, visual function, and optic nerve head structure.Keywords: ocular blood flow, carbonic anhydrase inhibitor, timolol, glaucoma, visual function, optic nerve head Adam M MossAlon HarrisBrent Sieskyet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 233-241 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Adam M Moss Alon Harris Brent Siesky et al Update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients
description	Adam M Moss, Alon Harris, Brent Siesky, Deepam Rusia, Kathleen M Williamson, Yochai ShoshaniDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USAAbstract: Topical hypotensive therapy with both timolol and carbonic anhydrase inhibitors has been shown to be efficacious at reducing intraocular pressure. Many prospective studies have also suggested that carbonic anhydrase inhibitors augment ocular blood flow and vascular regulation independent of their hypotensive effects. Although consistent in their findings, these studies must be cautiously interpreted due to the limitations of study design and specific blood flow imaging modalities. The purpose of this review is to appraise and critically evaluate the current body of literature investigating the effects of combined treatment with topical carbonic anhydrase inhibitors and timolol in patients with glaucoma with respect to ocular blood flow, visual function, and optic nerve head structure.Keywords: ocular blood flow, carbonic anhydrase inhibitor, timolol, glaucoma, visual function, optic nerve head
format	article
author	Adam M Moss Alon Harris Brent Siesky et al
author_facet	Adam M Moss Alon Harris Brent Siesky et al
author_sort	Adam M Moss
title	Update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients
title_short	Update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients
title_full	Update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients
title_fullStr	Update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients
title_full_unstemmed	Update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients
title_sort	update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/b5724d47208e4770a2269aa2f77c4e8f
work_keys_str_mv	AT adammmoss updateandcriticalappraisalofcombinedtimololandcarbonicanhydraseinhibitorsandtheeffectonocularbloodflowinglaucomapatients AT alonharris updateandcriticalappraisalofcombinedtimololandcarbonicanhydraseinhibitorsandtheeffectonocularbloodflowinglaucomapatients AT brentsiesky updateandcriticalappraisalofcombinedtimololandcarbonicanhydraseinhibitorsandtheeffectonocularbloodflowinglaucomapatients AT etal updateandcriticalappraisalofcombinedtimololandcarbonicanhydraseinhibitorsandtheeffectonocularbloodflowinglaucomapatients
_version_	1718403824901685248

Update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients

Ejemplares similares