microCLIP super learning framework uncovers functional transcriptome-wide miRNA interactions

AGO-PAR-CLIP is widely used for high-throughput miRNA target characterization. Here, the authors show that the previously neglected non-T-to-C clusters denote functional miRNA binding events, and develop microCLIP, a super learning framework that accurately detects miRNA interactions.

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Autores principales: Maria D. Paraskevopoulou, Dimitra Karagkouni, Ioannis S. Vlachos, Spyros Tastsoglou, Artemis G. Hatzigeorgiou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/b57772db0832471fa715d74f6ec08124
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