Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model

Abstract The studies presented were designed to highlight the impact of pancreatic enzymes on glycemic control and insulin response. Blood glucose and plasma insulin levels were monitored after intravenous, oral or direct gut glucose tolerance tests (GTT) in 6 pigs with an intact gastrointestinal tr...

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Autores principales:	Stefan G. Pierzynowski, Kateryna Goncharova, Peter C. Gregory, Björn Weström, Sergiy E. Podpryatov, Sergii S. Podpriatov, Jarosław Woliński, Hlib Repich, Nils Wierup, Liudmyla Lozinska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b5789c371c734b84ba7460ec21e6bd41
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spelling	oai:doaj.org-article:b5789c371c734b84ba7460ec21e6bd412021-12-02T11:40:32ZExperiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model10.1038/s41598-017-07387-22045-2322https://doaj.org/article/b5789c371c734b84ba7460ec21e6bd412017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07387-2https://doaj.org/toc/2045-2322Abstract The studies presented were designed to highlight the impact of pancreatic enzymes on glycemic control and insulin response. Blood glucose and plasma insulin levels were monitored after intravenous, oral or direct gut glucose tolerance tests (GTT) in 6 pigs with an intact gastrointestinal tract and in 12 pigs following duodenal-jejunal bypass (DJB) surgery. In the intact pigs, pancreatic enzymes (Creon®) given orally 1 h prior to the GTT, lowered the blood glucose levels during the oral and meal GTT and reduced the plasma insulin response during the intravenous and meal GTT. In DJB pigs, blood glucose and plasma insulin levels were higher following glucose loading into the by-passed biliopancreatic limb as compared to that following glucose loading orally or into the common intestinal limb. Infusion of amylase or amylase peptides together with glucose into the biliopancreatic limb lowered blood glucose levels in DJB pigs. These preliminary data suggest new, extra-digestive, actions of enteral pancreatic enzymes – probably amylase or its peptides – on glucose homeostasis, with an reduction in net glucose absorption into the blood and in insulin response. This ability of digestive enzymes (amylase) to reduce post-prandial hyperglycaemia in an insulin-independent manner could aid in preventing the development of obesity and diabetes.Stefan G. PierzynowskiKateryna GoncharovaPeter C. GregoryBjörn WeströmSergiy E. PodpryatovSergii S. PodpriatovJarosław WolińskiHlib RepichNils WierupLiudmyla LozinskaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stefan G. Pierzynowski Kateryna Goncharova Peter C. Gregory Björn Weström Sergiy E. Podpryatov Sergii S. Podpriatov Jarosław Woliński Hlib Repich Nils Wierup Liudmyla Lozinska Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model
description	Abstract The studies presented were designed to highlight the impact of pancreatic enzymes on glycemic control and insulin response. Blood glucose and plasma insulin levels were monitored after intravenous, oral or direct gut glucose tolerance tests (GTT) in 6 pigs with an intact gastrointestinal tract and in 12 pigs following duodenal-jejunal bypass (DJB) surgery. In the intact pigs, pancreatic enzymes (Creon®) given orally 1 h prior to the GTT, lowered the blood glucose levels during the oral and meal GTT and reduced the plasma insulin response during the intravenous and meal GTT. In DJB pigs, blood glucose and plasma insulin levels were higher following glucose loading into the by-passed biliopancreatic limb as compared to that following glucose loading orally or into the common intestinal limb. Infusion of amylase or amylase peptides together with glucose into the biliopancreatic limb lowered blood glucose levels in DJB pigs. These preliminary data suggest new, extra-digestive, actions of enteral pancreatic enzymes – probably amylase or its peptides – on glucose homeostasis, with an reduction in net glucose absorption into the blood and in insulin response. This ability of digestive enzymes (amylase) to reduce post-prandial hyperglycaemia in an insulin-independent manner could aid in preventing the development of obesity and diabetes.
format	article
author	Stefan G. Pierzynowski Kateryna Goncharova Peter C. Gregory Björn Weström Sergiy E. Podpryatov Sergii S. Podpriatov Jarosław Woliński Hlib Repich Nils Wierup Liudmyla Lozinska
author_facet	Stefan G. Pierzynowski Kateryna Goncharova Peter C. Gregory Björn Weström Sergiy E. Podpryatov Sergii S. Podpriatov Jarosław Woliński Hlib Repich Nils Wierup Liudmyla Lozinska
author_sort	Stefan G. Pierzynowski
title	Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model
title_short	Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model
title_full	Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model
title_fullStr	Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model
title_full_unstemmed	Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model
title_sort	experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b5789c371c734b84ba7460ec21e6bd41
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Experiments suggesting extra-digestive effects of enteral pancreatic amylase and its peptides on glucose homeostasis in a pig model

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