The conditional deletion of steroidogenic factor 1 (Nr5a1) in Sox9-Cre mice compromises testis differentiation

The conditional deletion of steroidogenic factor 1 (Nr5a1) in Sox9-Cre mice compromises testis differentiation

Abstract Steroidogenic factor 1 (NR5A1) is essential for gonadal development. To study the importance of NR5A1 during early gonadal sex differentiation, we generated Sox9-Cre-Nr5a1 conditional knockout (cKO) mice: Sox9-Cre;Nr5a1 flox/flox and Sox9-Cre;Nr5a1 flox/− mice. Double-immunostaining for NR5...

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Autores principales: Yayoi Ikeda, Ayako Tagami, Mamiko Maekawa, Akiko Nagai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/b57d436cdcb44e22987eecff4e5a9328
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