HLA DRB1* ASSOCIATION WITH REPRODUCTIVE DISORDERS IN WOMEN
Abstract. HLA DRB1* gene associations with idiopathic fetal losses and infertility were studied in women. It was shown that idiopathic fetal losses are associated with HLA DRB1*04 specificity, whereas infertility correlated with HLA DRB1*04/07 genotype. The associations revealed may indicate to a sp...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | article |
| Langue: | RU |
| Publié: |
SPb RAACI
2014
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/b580dbfa1a7d40d5a239e24e35a43601 |
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| Résumé: | Abstract. HLA DRB1* gene associations with idiopathic fetal losses and infertility were studied in women. It was shown that idiopathic fetal losses are associated with HLA DRB1*04 specificity, whereas infertility correlated with HLA DRB1*04/07 genotype. The associations revealed may indicate to a special role of autoimmune events in women during pregnancy. The authors suggest a hypothesis on existence of several immune modes of reproductive losses. HLA genotyping may be applied as a basic technique for their determination. |
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