An Integrated Approach Based on Network Pharmacology Combined with Experimental Verification Reveals AMPK/PI3K/Akt Signaling is an Important Way for the Anti-Type 2 Diabetic Activity of Silkworm Excrement

QR Code

An Integrated Approach Based on Network Pharmacology Combined with Experimental Verification Reveals AMPK/PI3K/Akt Signaling is an Important Way for the Anti-Type 2 Diabetic Activity of Silkworm Excrement

Huxinyue Duan,* Qing Zhang,* Jia Liu, Ruolan Li, Wei Peng, Chunjie Wu School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei Peng; Chunjie WuSchool of Pharmacy, Ch...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Duan H, Zhang Q, Liu J, Li R, Peng W, Wu C
Format:	article
Langue:	EN
Publié:	Dove Medical Press 2021
Sujets:	α-glucosidase insulin resistance network pharmacology silkworm excrement type 2 diabetes Specialties of internal medicine RC581-951
Accès en ligne:	https://doaj.org/article/b582d41c7c4b4e3bab1d5e4a28eebd3c
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Effects of silkworm excrement and water management on the accumulation of Cd and As in different varieties of rice and an assessment of their health risk
par: Tingting Li, et autres
Publié: (2021)

Comparison of Phenotypic and Genetic Performance of Local Silkworm Groups and Two Commercial Lines
par: Mirhosseini,Seyed Ziaeddin, et autres
Publié: (2010)

Novel Pathogenic Mucorales Identified Using the Silkworm Infection Model
par: Suresh Panthee, et autres
Publié: (2021)

Polyphenol content and pharmacological activities of Capsicum frutescens and C. chinense genotypes
par: Zulfikar D Sahid, et autres
Publié: (2021)

The Silkworm as a Source of Natural Antimicrobial Preparations: Efficacy on Various Bacterial Strains
par: Maristella Mastore, et autres
Publié: (2021)

Methyl ferulic acid ameliorates alcohol-induced hepatic insulin resistance via miR-378b-mediated activation of PI3K-AKT pathway
par: Yan Zhang, et autres
Publié: (2022)

A preliminary study of trace metals and porphyrins in excreta of Gentoo penguins (Pygoscelis papua) at two locations of the Antarctic Peninsula
par: Celis,J, et autres
Publié: (2012)

Fabrication and Biological Assessment of Antidiabetic α-Mangostin Loaded Nanosponges: In Vitro, In Vivo, and In Silico Studies
par: Faisal Usman, et autres
Publié: (2021)

Comparative study of the antidiabetic potential of Paederia foetida twig extracts and compounds from two different locations in Malaysia
par: Dai Chuan Tan, et autres
Publié: (2019)

GC/MS Analysis of Essential Oil and Enzyme Inhibitory Activities of <i>Syzygium cumini</i> (Pamposia) Grown in Egypt: Chemical Characterization and Molecular Docking Studies
par: Heba A. S. El-Nashar, et autres
Publié: (2021)

α-amylase and α-glucosidase antidiabetic potential of ten essential oils from Calophyllum inophyllum Linn
par: Emmanuel Onah Ojah, et autres
Publié: (2020)

Phytochemical Profile, α-Glucosidase, and α-Amylase Inhibition Potential and Toxicity Evaluation of Extracts from <i>Citrus aurantium</i> (L) Peel, a Valuable By-Product from Northeastern Morocco
par: Ouijdane Benayad, et autres
Publié: (2021)

Glycemic properties of soursop-based ice cream enriched with moringa leaf powder
par: Ayokunle O. Ademosun
Publié: (2021)

Design, modification, and bio-evaluation of salazinic acid derivatives
par: Nguyen-Kim-Tuyen Pham, et autres
Publié: (2022)

UPLC-MS/MS Profiling, Antioxidant, α-Glucosidase Inhibitory, Cholinesterase Inhibitory, and Cardiovascular Protection Potentials of Jialing 20 (<i>Morus multicaulis</i> Perr.) Mulberry Branch Extract
par: Wei Xiang, et autres
Publié: (2021)

α-Glucosidase Inhibitory and A Leptospermone Derivative from <i>Rhodomyrtus tomentosa</i>
par: Ferlinahayati Ferlinahayati, et autres
Publié: (2020)

Herbal Infusions as a Valuable Functional Food
par: Elżbieta Studzińska-Sroka, et autres
Publié: (2021)

Comparative phenolic content and antioxidant activity of some medicinal plant extracts prepared by choline chloride based green solvents and methanol
par: Pooja Choudhary, et autres
Publié: (2021)

Reduced Body Fat and Epididymal Adipose Apelin Expression Associated With Raspberry Ketone [4-(4-Hydroxyphenyl)-2-Butanone] Weight Gain Prevention in High-Fat-Diet Fed Mice
par: Lihong Hao, et autres
Publié: (2021)

Screening for potential antidiabetes and antioxidant activities of selected plants from East Kalimantan, Indonesia
par: RICO RAMADHAN, et autres
Publié: (2019)

Liraglutide ameliorates nonalcoholic fatty liver disease in diabetic mice via the IRS2/PI3K/Akt signaling pathway
par: Yang P, et autres
Publié: (2019)

Anti-Hyperglycaemic Evaluation of <i>Buddleia indica</i> Leaves Using In Vitro, In Vivo and In Silico Studies and Its Correlation with the Major Phytoconstituents
par: Sameh S. Elhady, et autres
Publié: (2021)

Digera muricata (L.) Mart. mediated synthesis of antimicrobial and enzymatic inhibitory zinc oxide bionanoparticles
par: Ashraf Naheed, et autres
Publié: (2021)

Inhibition of ?-glucosidase activity, metals content, and phytochemical profiling of Andrographis paniculata from different geographical origins based on FTIR and UHPLC-Q-Orbitrap HRMS metabolomics
par: Mohamad Rafi, et autres
Publié: (2021)

Examination the antioxidant potentials and antidiabetic properties of phenolic extracts of some Iranian honeys
par: Mahmoodreza Moein, et autres
Publié: (2022)

Time-Dependent Changes in Hepatic Sphingolipid Accumulation and PI3K/Akt/mTOR Signaling Pathway in a Rat Model of NAFLD
par: Klaudia Sztolsztener, et autres
Publié: (2021)

IN VITRO EFFECT OF TERPENOIDS - RICH EXTRACT OF Momordica charantia ON ALPHA GLUCOSIDASE ACTIVITY
par: A. B. SALLAU, et autres

Comparative Analysis of Biological Activity of Artificial and Wild Agarwood
par: Sheng Ma, et autres
Publié: (2021)

Add-On Therapy with DPP-4 Inhibitors May Improve Renal Function Decline in α-Glucosidase Inhibitor and Metformin Users: A Retrospective Observational Study
par: Osonoi T, et autres
Publié: (2020)

Molecular study of Pompe disease in Egyptian infants
par: Mona Essawi, et autres
Publié: (2021)

In vitro effect of terpenoid-rich extract of Momordica charantia on alpha glucosidase activity
par: AB SALLAU, et autres
Publié: (2018)

Alfredo López Austin, Francisco Toledo, Une vieille histoire de la merde, traduit de l’espagnol (Mexique) par Perig Pitrou et José M. Ruiz-Funes, Le Castor Astral, Cemca, Talence, Mexico, 2009, 125 p.
par: Patrick Lesbre
Publié: (2012)

Efecto de enzimas proteolíticas y de la abstinencia sexual en la cuantificación bioquímica de alfa-glucosidasa en plasma seminal humano
par: Peña S,Patricio, et autres
Publié: (2001)

Phytochemical Screening and Antioxidant Activity of Seven Native Species Growing in the Forests of Southern Chilean Patagonia
par: Merly de Armas-Ricard, et autres
Publié: (2021)

Estrogen receptor variant ERα46 and insulin receptor drive in primary breast cancer cells growth effects and interleukin 11 induction prompting the motility of cancer‐associated fibroblasts
par: Francesca Cirillo, et autres
Publié: (2021)

IGF-1 Facilitates Cartilage Reconstruction by Regulating PI3K/AKT, MAPK, and NF-kB Signaling in Rabbit Osteoarthritis
par: Hossain MA, et autres
Publié: (2021)

Thrombospondin 2 Promotes IL-6 Production in Osteoarthritis Synovial Fibroblasts via the PI3K/AKT/NF-κB Pathway
par: Hou CH, et autres
Publié: (2021)

Production of enzymes from Lichtheimia ramosa using Brazilian savannah fruit wastes as substrate on solid state bioprocessess
par: Silva,Cinthia Aparecida de Andrade, et autres
Publié: (2013)

Evaluation of the inhibitory potentials of selected compounds from Costus spicatus (Jacq.) rhizome towards enzymes associated with insulin resistance in polycystic ovarian syndrome: an in silico study
par: Fehintoluwa Joy Femi-Olabisi, et autres
Publié: (2021)

Fuzhu jiangtang granules combined with metformin reduces insulin resistance in skeletal muscle of diabetic rats via PI3K/Akt signaling
par: Yunsong Cao, et autres
Publié: (2019)