Post intrastromal corneal ring segments insertion complicated by Candida parapsilosis keratitis

Bradley M Mitchell,1 A John Kanellopoulos,2 Ramon L Font31Eclipse IS Consulting, Rosenberg, TX, 2Department of Ophthalmology, New York University Medical School, New York City, NY, 3Department of Ophthalmology, Ophthalmic Pathology Laboratory, Cullen Eye Institute, Baylor College of Medicine, Housto...

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Autores principales:	Mitchell BM, Kanellopoulos AJ, Font RL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/b583e67ca1d142b1aea9050b8eb2e5ce
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spelling	oai:doaj.org-article:b583e67ca1d142b1aea9050b8eb2e5ce2021-12-02T07:20:15ZPost intrastromal corneal ring segments insertion complicated by Candida parapsilosis keratitis1177-54671177-5483https://doaj.org/article/b583e67ca1d142b1aea9050b8eb2e5ce2013-02-01T00:00:00Zhttp://www.dovepress.com/post-intrastromal-corneal-ring-segments-insertion-complicated-by-candi-a12321https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Bradley M Mitchell,1 A John Kanellopoulos,2 Ramon L Font31Eclipse IS Consulting, Rosenberg, TX, 2Department of Ophthalmology, New York University Medical School, New York City, NY, 3Department of Ophthalmology, Ophthalmic Pathology Laboratory, Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USAAbstract: This case report describes the clinical and histopathologic features, including molecular confirmation, of fungal keratitis after intrastromal corneal ring segments placement for keratoconus. A 52-year-old woman underwent insertion of Intacs&reg; corneal implants for treatment of keratoconus. Extrusion of the implants was noted 5 months post insertion and replaced. Three months later, monocular infiltrates and an epithelial defect were observed. The Intacs were removed and the infiltrates were treated with ofloxacin and prednisolone acetate. Microbial cultures and stains were negative. The patient demonstrated flares and exacerbation one month later. Mycoplasma and/or fungus were suspected and treated without improvement. Therapeutic keratoplasty was performed 10 months following initial placement of the corneal ring implants. The keratectomy specimen was analyzed by light microscopy and a panfungal polymerase chain reaction assay. A histopathologic diagnosis of Candida parapsilosis keratitis was made and confirmed by polymerase chain reaction. One year postoperatively, a systemic workup of the patient was done with no signs of recurrence. This rare report of fungal keratitis following Intacs insertion is the first reported case of C. parapsilosis complicating Intacs implantation.Keywords: keratoconus, Intacs&reg;, polymerase chain reaction, PCR, molecular diagnosis, histopathologyMitchell BMKanellopoulos AJFont RLDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 443-448 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Mitchell BM Kanellopoulos AJ Font RL Post intrastromal corneal ring segments insertion complicated by Candida parapsilosis keratitis
description	Bradley M Mitchell,1 A John Kanellopoulos,2 Ramon L Font31Eclipse IS Consulting, Rosenberg, TX, 2Department of Ophthalmology, New York University Medical School, New York City, NY, 3Department of Ophthalmology, Ophthalmic Pathology Laboratory, Cullen Eye Institute, Baylor College of Medicine, Houston, TX, USAAbstract: This case report describes the clinical and histopathologic features, including molecular confirmation, of fungal keratitis after intrastromal corneal ring segments placement for keratoconus. A 52-year-old woman underwent insertion of Intacs&reg; corneal implants for treatment of keratoconus. Extrusion of the implants was noted 5 months post insertion and replaced. Three months later, monocular infiltrates and an epithelial defect were observed. The Intacs were removed and the infiltrates were treated with ofloxacin and prednisolone acetate. Microbial cultures and stains were negative. The patient demonstrated flares and exacerbation one month later. Mycoplasma and/or fungus were suspected and treated without improvement. Therapeutic keratoplasty was performed 10 months following initial placement of the corneal ring implants. The keratectomy specimen was analyzed by light microscopy and a panfungal polymerase chain reaction assay. A histopathologic diagnosis of Candida parapsilosis keratitis was made and confirmed by polymerase chain reaction. One year postoperatively, a systemic workup of the patient was done with no signs of recurrence. This rare report of fungal keratitis following Intacs insertion is the first reported case of C. parapsilosis complicating Intacs implantation.Keywords: keratoconus, Intacs&reg;, polymerase chain reaction, PCR, molecular diagnosis, histopathology
format	article
author	Mitchell BM Kanellopoulos AJ Font RL
author_facet	Mitchell BM Kanellopoulos AJ Font RL
author_sort	Mitchell BM
title	Post intrastromal corneal ring segments insertion complicated by Candida parapsilosis keratitis
title_short	Post intrastromal corneal ring segments insertion complicated by Candida parapsilosis keratitis
title_full	Post intrastromal corneal ring segments insertion complicated by Candida parapsilosis keratitis
title_fullStr	Post intrastromal corneal ring segments insertion complicated by Candida parapsilosis keratitis
title_full_unstemmed	Post intrastromal corneal ring segments insertion complicated by Candida parapsilosis keratitis
title_sort	post intrastromal corneal ring segments insertion complicated by candida parapsilosis keratitis
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/b583e67ca1d142b1aea9050b8eb2e5ce
work_keys_str_mv	AT mitchellbm postintrastromalcornealringsegmentsinsertioncomplicatedbycandidaparapsilosiskeratitis AT kanellopoulosaj postintrastromalcornealringsegmentsinsertioncomplicatedbycandidaparapsilosiskeratitis AT fontrl postintrastromalcornealringsegmentsinsertioncomplicatedbycandidaparapsilosiskeratitis
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Post intrastromal corneal ring segments insertion complicated by Candida parapsilosis keratitis

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