The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome

The NLRP3 inflammasome is important for inducing IL-1β and IL-18 inflammatory responses. Here the authors show, by generating and characterizing Peli2 deficient mice and immune cells, that an E3 ubiquitin ligase Pellino2 promotes inflammasome priming by inducing NLRP3 ubiquitination and by targeting...

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Autores principales:	Fiachra Humphries, Ronan Bergin, Ruaidhri Jackson, Nezira Delagic, Bingwei Wang, Shuo Yang, Alice V. Dubois, Rebecca J. Ingram, Paul N. Moynagh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b58516ad7891424abe4c474bec6c5209
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spelling	oai:doaj.org-article:b58516ad7891424abe4c474bec6c52092021-12-02T17:32:15ZThe E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome10.1038/s41467-018-03669-z2041-1723https://doaj.org/article/b58516ad7891424abe4c474bec6c52092018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03669-zhttps://doaj.org/toc/2041-1723The NLRP3 inflammasome is important for inducing IL-1β and IL-18 inflammatory responses. Here the authors show, by generating and characterizing Peli2 deficient mice and immune cells, that an E3 ubiquitin ligase Pellino2 promotes inflammasome priming by inducing NLRP3 ubiquitination and by targeting IRAK1.Fiachra HumphriesRonan BerginRuaidhri JacksonNezira DelagicBingwei WangShuo YangAlice V. DuboisRebecca J. IngramPaul N. MoynaghNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fiachra Humphries Ronan Bergin Ruaidhri Jackson Nezira Delagic Bingwei Wang Shuo Yang Alice V. Dubois Rebecca J. Ingram Paul N. Moynagh The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome
description	The NLRP3 inflammasome is important for inducing IL-1β and IL-18 inflammatory responses. Here the authors show, by generating and characterizing Peli2 deficient mice and immune cells, that an E3 ubiquitin ligase Pellino2 promotes inflammasome priming by inducing NLRP3 ubiquitination and by targeting IRAK1.
format	article
author	Fiachra Humphries Ronan Bergin Ruaidhri Jackson Nezira Delagic Bingwei Wang Shuo Yang Alice V. Dubois Rebecca J. Ingram Paul N. Moynagh
author_facet	Fiachra Humphries Ronan Bergin Ruaidhri Jackson Nezira Delagic Bingwei Wang Shuo Yang Alice V. Dubois Rebecca J. Ingram Paul N. Moynagh
author_sort	Fiachra Humphries
title	The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome
title_short	The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome
title_full	The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome
title_fullStr	The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome
title_full_unstemmed	The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome
title_sort	e3 ubiquitin ligase pellino2 mediates priming of the nlrp3 inflammasome
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b58516ad7891424abe4c474bec6c5209
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The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome

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