Effects of maoto (ma-huang-tang) on host lipid mediator and transcriptome signature in influenza virus infection

Abstract Maoto, a traditional kampo medicine, has been clinically prescribed for influenza infection and is reported to relieve symptoms and tissue damage. In this study, we evaluated the effects of maoto as an herbal multi-compound medicine on host responses in a mouse model of influenza infection....

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Autores principales:	Akinori Nishi, Noriko Kaifuchi, Chika Shimobori, Katsuya Ohbuchi, Seiichi Iizuka, Aiko Sugiyama, Keisuke Ogura, Masahiro Yamamoto, Haruo Kuroki, Shigeki Nabeshima, Ayako Yachie, Yukiko Matsuoka, Hiroaki Kitano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b5861bd758d54473b0e9cfbbe5346d2a
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spelling	oai:doaj.org-article:b5861bd758d54473b0e9cfbbe5346d2a2021-12-02T12:11:34ZEffects of maoto (ma-huang-tang) on host lipid mediator and transcriptome signature in influenza virus infection10.1038/s41598-021-82707-12045-2322https://doaj.org/article/b5861bd758d54473b0e9cfbbe5346d2a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82707-1https://doaj.org/toc/2045-2322Abstract Maoto, a traditional kampo medicine, has been clinically prescribed for influenza infection and is reported to relieve symptoms and tissue damage. In this study, we evaluated the effects of maoto as an herbal multi-compound medicine on host responses in a mouse model of influenza infection. On the fifth day of oral administration to mice intranasally infected with influenza virus [A/PR/8/34 (H1N1)], maoto significantly improved survival rate, decreased viral titer, and ameliorated the infection-induced phenotype as compared with control mice. Analysis of the lung and plasma transcriptome and lipid mediator metabolite profile showed that maoto altered the profile of lipid mediators derived from ω-6 and ω-3 fatty acids to restore a normal state, and significantly up-regulated the expression of macrophage- and T-cell-related genes. Collectively, these results suggest that maoto regulates the host’s inflammatory response by altering the lipid mediator profile and thereby ameliorating the symptoms of influenza.Akinori NishiNoriko KaifuchiChika ShimoboriKatsuya OhbuchiSeiichi IizukaAiko SugiyamaKeisuke OguraMasahiro YamamotoHaruo KurokiShigeki NabeshimaAyako YachieYukiko MatsuokaHiroaki KitanoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Akinori Nishi Noriko Kaifuchi Chika Shimobori Katsuya Ohbuchi Seiichi Iizuka Aiko Sugiyama Keisuke Ogura Masahiro Yamamoto Haruo Kuroki Shigeki Nabeshima Ayako Yachie Yukiko Matsuoka Hiroaki Kitano Effects of maoto (ma-huang-tang) on host lipid mediator and transcriptome signature in influenza virus infection
description	Abstract Maoto, a traditional kampo medicine, has been clinically prescribed for influenza infection and is reported to relieve symptoms and tissue damage. In this study, we evaluated the effects of maoto as an herbal multi-compound medicine on host responses in a mouse model of influenza infection. On the fifth day of oral administration to mice intranasally infected with influenza virus [A/PR/8/34 (H1N1)], maoto significantly improved survival rate, decreased viral titer, and ameliorated the infection-induced phenotype as compared with control mice. Analysis of the lung and plasma transcriptome and lipid mediator metabolite profile showed that maoto altered the profile of lipid mediators derived from ω-6 and ω-3 fatty acids to restore a normal state, and significantly up-regulated the expression of macrophage- and T-cell-related genes. Collectively, these results suggest that maoto regulates the host’s inflammatory response by altering the lipid mediator profile and thereby ameliorating the symptoms of influenza.
format	article
author	Akinori Nishi Noriko Kaifuchi Chika Shimobori Katsuya Ohbuchi Seiichi Iizuka Aiko Sugiyama Keisuke Ogura Masahiro Yamamoto Haruo Kuroki Shigeki Nabeshima Ayako Yachie Yukiko Matsuoka Hiroaki Kitano
author_facet	Akinori Nishi Noriko Kaifuchi Chika Shimobori Katsuya Ohbuchi Seiichi Iizuka Aiko Sugiyama Keisuke Ogura Masahiro Yamamoto Haruo Kuroki Shigeki Nabeshima Ayako Yachie Yukiko Matsuoka Hiroaki Kitano
author_sort	Akinori Nishi
title	Effects of maoto (ma-huang-tang) on host lipid mediator and transcriptome signature in influenza virus infection
title_short	Effects of maoto (ma-huang-tang) on host lipid mediator and transcriptome signature in influenza virus infection
title_full	Effects of maoto (ma-huang-tang) on host lipid mediator and transcriptome signature in influenza virus infection
title_fullStr	Effects of maoto (ma-huang-tang) on host lipid mediator and transcriptome signature in influenza virus infection
title_full_unstemmed	Effects of maoto (ma-huang-tang) on host lipid mediator and transcriptome signature in influenza virus infection
title_sort	effects of maoto (ma-huang-tang) on host lipid mediator and transcriptome signature in influenza virus infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b5861bd758d54473b0e9cfbbe5346d2a
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Effects of maoto (ma-huang-tang) on host lipid mediator and transcriptome signature in influenza virus infection

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