A Simple Flow-Cytometric Method Measuring B Cell Surface Immunoglobulin Avidity Enables Characterization of Affinity Maturation to Influenza A Virus

A Simple Flow-Cytometric Method Measuring B Cell Surface Immunoglobulin Avidity Enables Characterization of Affinity Maturation to Influenza A Virus

ABSTRACT Antibody (Ab) affinity maturation enables an individual to maintain immunity to an increasing number of pathogens within the limits of a total Ig production threshold. A better understanding of this process is critical for designing vaccines that generate optimal Ab responses to pathogens....

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Autores principales: Gregory M. Frank, Davide Angeletti, William L. Ince, James S. Gibbs, Surender Khurana, Adam K. Wheatley, Edward E. Max, Adrian B. McDermott, Hana Golding, James Stevens, Jack R. Bennink, Jonathan W. Yewdell
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2015
Materias:
Microbiology
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Acceso en línea:https://doaj.org/article/b5878bacd8b24a17bf9b60102e41b1e6
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