Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications

Metabolism changes can modulate immune responses in many contexts, and vice versa. Here the authors associate metabolomic, as well as cytokine and chemokine, data from stratified COVID-19 patients to find that arginine, tryptophan and purine metabolic pathways correlate with hyperproliferation, thus...

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Autores principales:	Nan Xiao, Meng Nie, Huanhuan Pang, Bohong Wang, Jieli Hu, Xiangjun Meng, Ke Li, Xiaorong Ran, Quanxin Long, Haijun Deng, Na Chen, Shao Li, Ni Tang, Ailong Huang, Zeping Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b58960adabc94fd2b285cde23e2b847e
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spelling	oai:doaj.org-article:b58960adabc94fd2b285cde23e2b847e2021-12-02T13:15:55ZIntegrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications10.1038/s41467-021-21907-92041-1723https://doaj.org/article/b58960adabc94fd2b285cde23e2b847e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21907-9https://doaj.org/toc/2041-1723Metabolism changes can modulate immune responses in many contexts, and vice versa. Here the authors associate metabolomic, as well as cytokine and chemokine, data from stratified COVID-19 patients to find that arginine, tryptophan and purine metabolic pathways correlate with hyperproliferation, thus hinting at potential therapeutic targets for severe COVID-19 patients.Nan XiaoMeng NieHuanhuan PangBohong WangJieli HuXiangjun MengKe LiXiaorong RanQuanxin LongHaijun DengNa ChenShao LiNi TangAilong HuangZeping HuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nan Xiao Meng Nie Huanhuan Pang Bohong Wang Jieli Hu Xiangjun Meng Ke Li Xiaorong Ran Quanxin Long Haijun Deng Na Chen Shao Li Ni Tang Ailong Huang Zeping Hu Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications
description	Metabolism changes can modulate immune responses in many contexts, and vice versa. Here the authors associate metabolomic, as well as cytokine and chemokine, data from stratified COVID-19 patients to find that arginine, tryptophan and purine metabolic pathways correlate with hyperproliferation, thus hinting at potential therapeutic targets for severe COVID-19 patients.
format	article
author	Nan Xiao Meng Nie Huanhuan Pang Bohong Wang Jieli Hu Xiangjun Meng Ke Li Xiaorong Ran Quanxin Long Haijun Deng Na Chen Shao Li Ni Tang Ailong Huang Zeping Hu
author_facet	Nan Xiao Meng Nie Huanhuan Pang Bohong Wang Jieli Hu Xiangjun Meng Ke Li Xiaorong Ran Quanxin Long Haijun Deng Na Chen Shao Li Ni Tang Ailong Huang Zeping Hu
author_sort	Nan Xiao
title	Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications
title_short	Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications
title_full	Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications
title_fullStr	Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications
title_full_unstemmed	Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications
title_sort	integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in covid-19 patients with therapeutic implications
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b58960adabc94fd2b285cde23e2b847e
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Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications

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