An interdigit signalling centre instructs coordinate phalanx-joint formation governed by 5′Hoxd–Gli3 antagonism
The molecular mechanisms governing digit joint specification are poorly understood. Here, the authors identify the 5′Hoxd–Gli3 balance as a key regulator of the net interdigital Bmp signalling level in mouse, which in turn regulates phalanx and joint formation.
Guardado en:
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2016
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/b589df54b71a442db003ba86c874cc67 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | The molecular mechanisms governing digit joint specification are poorly understood. Here, the authors identify the 5′Hoxd–Gli3 balance as a key regulator of the net interdigital Bmp signalling level in mouse, which in turn regulates phalanx and joint formation. |
|---|